胶红酵母产类胡萝卜素的研究进展  

Research Progress in Production of Carotenoids by Rhodotorula mucilaginosa

作　　者：张红 赵鑫 吴昊 温彤 马勇[1] ZHANG Hong;ZHAO Xin;WU Hao;WEN Tong;MA Yong(School of Biological Science and Technology,Baotou Teachers′College,Baotou 014030,China)

机构地区：[1]包头师范学院生物科学与技术学院,内蒙古包头014030

出　　处：《化学与生物工程》2023年第11期1-6,27,共7页Chemistry & Bioengineering

基　　金：包头师范学院黄河流域生态保护和高质量发展研究院科研项目(BSYHY202214),内蒙古自治区高等学校科学技术研究项目(NJZY22022),包头师范学院一般项目(BSYKJ2021-ZY05),内蒙古自然科学基金项目(2022MS03018)。

摘　　要：类胡萝卜素属于萜类化合物,在染色、食品、医药等领域具有很高的应用价值。类胡萝卜素常采用化学合成法、植物提取法和微生物发酵法得到,其中微生物发酵法最具发展前景。综述了胶红酵母产类胡萝卜素的代谢途径、优化菌株培养策略及类胡萝卜素提取策略,并介绍了利用基因工程手段调控关键酶基因的表达水平来提高类胡萝卜素产量及控制代谢途径筛选类胡萝卜素高产菌株,为类胡萝卜素的工业化生产提供了理论依据。Carotenoids belong to terpenoid compounds,which have high application values in dyeing,food,medicine,and other fields.Carotenoids are often obtained by chemical synthesis,plant extraction,and microbial fermentation,among which,microbial fermentation is the most promising method.In this paper,we review the metabolic pathway of Rhodotorula mucilaginosa for production of carotenoids,the optimal strain culture strategy,and the extraction strategy of carotenoids.Moreover,we introduce that the expression level of key enzyme genes is regulated by gene engineering to improve carotenoids production and the metabolic pathway is controlled to screen the high-yield carotenoids-producing strains,which provides a theoretical basis for the industrial production of carotenoids.

关 键 词：胶红酵母 天然类胡萝卜素 色素 提取 控制代谢途径 

分 类 号：TQ926.4[轻工技术与工程—发酵工程] Q936[生物学—微生物学]