营养不良性视神经病变发病机制的研究进展  

Advances in pathogenesis of nutritional optic neuropathy

作　　者：杨雪莉 毛俊峰[2] Yang Xueli;Mao Junfeng(Department of Ophthalmology,Wuxi Huishan District People's Hospital,Wuxi Jiangsu 214187,China;Hunan Provincial Key Laboratory of Ophthalmology,Ophthalmology Center,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]无锡市惠山区人民医院眼科,江苏无锡214187 [2]中南大学湘雅医院眼科中心眼科学湖南省重点实验室,长沙410008

出　　处：《国际眼科纵览》2023年第5期400-405,共6页International Review of Ophthalmology

摘　　要：营养不良性视神经病变(nutritional optic neuropathy,NON)是一类由于营养元素缺乏或代谢障碍引起的视神经功能异常性疾病,主要特征为双侧渐进性、无痛性视力损害,常与营养不良或不良饮食习惯相关。长期吸烟、酒精滥用、慢性腹泻和减肥手术等危险因素也增加了易感个体患病的可能性。目前普遍认为NON的发病机制以线粒体功能障碍为主,氧化应激损伤和轴突脱髓鞘等也在疾病发生发展中发挥作用。Nutritional optic neuropathy(NON)is a dysfunction of the optic nerve caused by nutritional deficiencies or metabolic disorders.It is primarily characterized by progressive bilateral and painless loss of central visual acuity associated with malnutrition or poor eating habits.There are also certain risk factors make the patient more susceptible to optic neuropathy including long-term smoking,alcohol abuse,chronic diarrhea and bariatric surgery.It is widely accepted that the pathogenesis of NON are dominated by the theory of mitochondrial dysfunction.Oxidative stress damage and axon demyelination also play important roles in the development of the disease.

关 键 词：营养不良性视神经病变 营养不良 维生素 金属元素 

分 类 号：R774.6[医药卫生—眼科]