人类疱疹病毒和人乳头瘤病毒在翼状胬肉发病中的作用  

Role of human herpesvirus and human papillomavirus in the pathogenesis of pterygium

作　　者：周朔雯 许叶圣[1] 郑利斌 姚玉峰[1] Zhou Shuowen;Xu Yesheng;Zheng Libin;Yao Yufeng(Department of Ophthalmology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Key Laboratory for Corneal Diseases Research of Zhejiang Province,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院眼科、浙江省角膜病研究重点实验室,杭州310000

出　　处：《国际眼科纵览》2023年第5期471-474,共4页International Review of Ophthalmology

基　　金：国家自然科学基金(U20A20387)

摘　　要：原发性翼状胬肉是一种由结膜部位突破角膜缘,进入透明角膜形成的三角形纤维血管组织病变。其发病机制尚不明确,紫外线、风沙、病毒感染等因素可能参与了其发生过程。病原学研究证实,在翼状胬肉组织中检出人类疱疹病毒和人乳头瘤病毒,但其检出率差异较大,提示病毒可能仅作为其中一个因素,与其他因素共同作用导致翼状胬肉的发生与复发。如果病毒在翼状胬肉发病中的作用被证实,抗病毒药物或疫苗可成为翼状胬肉治疗的研究新方向。Primary pterygium is a triangular fibrovascular lesion originating from the conjunctiva that often breaks through the limbus and extends to the cornea.The pathogenesis of primary pterygium has yet to be fully elucidated,but ultraviolet light,wind and dust,viral infection,and other factors may be involved in it.Pathogenetic researches indicate that human herpesvirus(HHV)and human papillomavirus(HPV)are detected in pterygium tissue,but the prevalence varies greatly,suggesting that the virus infection may only act as one of the factors in pterygium pathogenesis or recurrence.If the involvement of the virus is confirmed in pterygium pathogenesis,antiviral medications or vaccination may become a new research direction for pterygium therapy.

关 键 词：翼状胬肉 人类疱疹病毒 人乳头瘤病毒 

分 类 号：R777.33[医药卫生—眼科]