人类身高推断的分子生物学研究进展  

Research Progress on Molecular Biology of Human Height Estimation

作　　者：王中华 李淑瑾 WANG Zhong-hua;LI Shu-jin(College of Forensic Medicine of Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北医科大学法医学院,河北石家庄050017

出　　处：《法医学杂志》2023年第5期487-492,500,共7页Journal of Forensic Medicine

基　　金：国家自然科学基金资助项目(82072118);河北省自然科学基金资助项目(H2021206451);河北省创新能力提升计划资助项目(225A5602D)。

摘　　要：身高作为一项重要的人体测量学特征,不仅有助于认识其他人类学特征和遗传风险因素,也是法医DNA表型研究的重要内容。对于身高的准确推断可以更完整地提供嫌疑人的表型信息,为案件侦破提供帮助。近年分子生物学技术和生物信息学快速发展,身高相关的遗传学研究也取得一定研究进展。本文主要从遗传变异和表观遗传两方面阐述身高推断的研究进展,并对今后研究方向进行展望。As an important anthropometric characteristic,human height not only contributes to the recogni-tion of other anthropological characteristics and genetic risk factors,but also is an important part of forensic DNA phenotyping studies.Accurate estimation of height can provide more complete informa-tion about the phenotype of suspects and provide help to solve cases.In recent years,having ben-efited from the rapid development of molecular biological techniques and bioinformatics,height-related genetics research has made some progress.This paper describes the research progress of human height estimation from the genetic variation and the epigenetic inheritance perspectives and looks into the fu-ture research direction.

关 键 词：法医遗传学 分子生物学 身高推断 遗传变异 表观遗传 综述 

分 类 号：R89[医药卫生—法医学] DF795.2[医药卫生—临床医学] D919.2[政治法律—诉讼法学]