曲克芦丁脑蛋白水解物联合依达拉奉治疗急性脑梗死患者的效果  

Effects of Troxerutin brain protein hydrolysate combined with Edaravone in treatment of patients with acute cerebral infarction

作　　者：高阳阳 吴相培 姜朋娟 GAO Yangyang;WU Xiangpei;JIANG Pengjuan(Second Ward of Department of Neurology of Xinmi First People’s Hospital,Zhengzhou 452370 Henan,China)

机构地区：[1]新密市第一人民医院神经内科二病区,河南郑州452370

出　　处：《中国民康医学》2023年第21期19-22,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨曲克芦丁脑蛋白水解物联合依达拉奉治疗急性脑梗死患者的效果。方法:回顾性分析2021年3月至2023年1月该院收治的89例急性脑梗死患者的临床资料,根据患者治疗方式不同分为对照组45例和观察组44例。两组均予以静脉溶栓、吸氧、降血脂、抗血小板等常规治疗。在此基础上,对照组采用依达拉奉注射液治疗,观察组在对照组基础上联合曲克芦丁脑蛋白水解物注射液治疗。治疗2周后,比较两组临床疗效,治疗前后血清神经激素[脑钠肽(BNP)、血管紧张素Ⅱ(AngⅡ)]水平、脑动脉血流速度,以及不良反应发生率。结果:观察组治疗总有效率为97.73%(43/44),高于对照组的71.11%(32/45),差异有统计学意义(P<0.05);治疗后,观察组大脑前动脉、大脑中动脉、大脑后动脉的血流速度均高于对照组,血清AngⅡ、BNP水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:曲克芦丁脑蛋白水解物联合依达拉奉治疗急性脑梗死患者效果确切,可提高脑动脉血流速度,降低血清AngⅡ、BNP水平,效果优于单用依达拉奉治疗。Objective:To investigate effects of Troxerutin brain protein hydrolysate combined with Edaravone in treatment of patients with acute cerebral infarction.Methods:The clinical data of 89 patients with acute cerebral infarction admitted to this hospital from March 2021 to January 2023 were retrospectively analyzed.According to the different treatment methods,these patients were divided into control group(45 cases)and observation group(44 cases).Both groups were given intravenous thrombolysis,oxygen inhalation,lipid-lowering,antiplatelet and other conventional treatment.On this basis,the control group was treated with Edaravone injection,while the observation group was treated with Troxerutin brain protein hydrolysate injection on the basis of that of the control group.After 2 weeks of treatment,the clinical efficacy,the serum neurohormones[brain natriuretic peptide(BNP),angiotensinⅡ(AngⅡ)]levels,the cerebral artery blood flow velocity,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 97.73%(43/44),which was higher than 71.11%(32/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the blood flow velocities of anterior cerebral artery,middle cerebral artery and posterior cerebral artery in the observation group was higher than those in the control group,the levels of serum AngⅡand BNP were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Troxerutin brain protein hydrolysate combined with Edaravone is effective in the treatment of the patients with acute cerebral infarction,which can improve the blood flow velocity of cerebral artery and reduce the levels of AngⅡand BNP.Moreover,it is superior to single Edaravone treatment.

关 键 词：急性脑梗死 曲克芦丁脑蛋白水解物 依达拉奉 神经激素 脑动脉血流速度 

分 类 号：R743.3[医药卫生—神经病学与精神病学]