改良根治术联合他莫昔芬治疗早期乳腺癌的临床疗效  

Clinical efficacy of modified radical mastectomy combined with tamoxifen in the treatment of early breast cancer

作　　者：叶进良 唐小君 吴朋容 YE Jinliang;TANG Xiaojun;WU Pengrong(Department of Thoracic and Breast Surgery,the Third Affiliated Hospital of Guangdong Medical University/Shunde Longjiang Hospital,Foshan,Guangdong,528300,China)

机构地区：[1]广东医科大学附属第三医院/顺德龙江医院甲乳外科,广东佛山528300

出　　处：《当代医学》2023年第21期91-93,共3页Contemporary Medicine

摘　　要：目的探究改良根治术联合他莫昔芬治疗早期乳腺癌的临床疗效。方法回顾性分析2016年1月至2018年12月本院收治并确诊的100例早期乳腺癌患者的临床资料,根据治疗方案的不同分为对照组与研究组,每组50例。对照组采用改良根治术治疗,研究组在对照组基础上给予他莫昔芬治疗,比较两组0~12、13~24个月生存率和复发率与治疗前后人乳腺珠蛋白、转化生长因子β_(1)水平及并发症发生情况。结果研究组0~12、13~24个月生存率均明显高于对照组,0~12、13~24个月复发率均明显低于对照组,差异有统计学意义(P<0.05)。治疗前,两组人乳腺珠蛋白、转化生长因子β_(1)水平比较差异无统计学意义;治疗后,两组人乳腺珠蛋白、转化生长因子β_(1)水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率为10.00%,低于对照组的30.00%,差异有统计学意义(P<0.05)。结论改良根治术联合他莫昔芬治疗早期乳腺癌效果显著,不仅可有效降低患者复发率及人乳腺珠蛋白和转化生长因子β_(1)水平,还有利于延长患者生存期,减少并发症的发生。Objective To explore the clinical efficacy of modified radical mastectomy combined with tamoxifen in the treatment of early breast cancer.Methods The clinical data of 100 patients with early breast cancer admitted and diagnosed in our hospital from January 2016 to December 2018 were retrospectively analyzed,and they were divided into the control group and the study group according to different treatment plans,with 50 cases in each group.The control group was treated with modified radical surgery,and the study group was treated with tamoxifen on the basis of the control group,the survival rate and recurrence rate at 0-12 and 13-24 months,the levels of human mammary globin and transforming growth factorβ_(1) before and after treatment and the incidence of complications were compared between the two groups.Results The survival rates at 0-12 and 13-24 months in the study group were significantly higher than those in the control group,and the recurrence rate at 0-12 and 13-24 months were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of human mammary globin and transforming growth factorβ_(1) between the two groups;after treatment,the levels of human mammary globin and transforming growth factorβ_(1) of the two groups were lower than those before treatment,and the levels of human mammary globin and transforming growth factorβ_(1) in the study group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the study group was 10.00%,which was significantly lower than 30.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Modified radical mastectomy combined with tamoxifen has significant effect in the treatment of early breast cancer,can not only effectively reduce the recurrence rate and the levels of human mammaglobin and transforming growth factorβ_(1) of pat

关 键 词：早期乳腺癌 改良根治术 他莫昔芬 人乳腺珠蛋白 转化生长因子β_(1) 并发症 

分 类 号：R737.9[医药卫生—肿瘤]