外周血清VEGF在食管鳞癌患者化疗前后变化及临床意义  

Changes in peripheral serum VEGF levels before and after chemotherapy in patients with esophageal squamous cell carcinoma and its clinical significance

作　　者：杨露露 苗战会[2] 康小红[2] YANG Lulu;MIAO Zhanghui;KANG Xiaohong(Department of Oncology,Xinyang People’s Hospital,Henan,Xinyang 464000,China;不详)

机构地区：[1]河南省信阳市人民医院,464000 [2]新乡医学院第一附属医院肿瘤科

出　　处：《河北医药》2023年第21期3226-3229,3234,共5页Hebei Medical Journal

基　　金：国家自然科学基金项目(编号:81874392)。

摘　　要：目的观察外周血清中血管内皮生长因子(VEGF)表达水平在食管鳞癌患者化疗期间的变化情况,探讨其临床意义。方法筛选2018年8月至2019年12月病理学检查诊断为食管鳞癌的87例初治患者作为病例组,选取40例同期健康体检者作为对照组,比较2组外周血清VEGF水平,并分析VEGF表达水平与临床病理参数的相关性。病例组中62例患者接受紫杉醇联合顺铂化疗,比较化疗前后血清VEGF水平,分析其与临床疗效之间的关系。使用受试者工作特征曲线(ROC)评价血清VEGF对食管鳞癌的诊断效能。结果病例组患者外周血清VEGF水平显著高于对照组(P<0.05)。食管鳞癌患者血清VEGF异常高表达与疾病进展显著相关(P<0.05)。化疗前血清VEGF水平与化疗疗效无显著相关性(P>0.05)。有效组患者化疗后血清VEGF水平与化疗前比较显著降低(P<0.05);无效组患者化疗后血清VEGF水平较化疗前显著升高(P<0.05)。血清VEGF水平诊断食管鳞癌的AUC为0.863,最佳诊断界值为229.74 pg/ml。结论VEGF在食管鳞癌患者外周血清中异常高表达,并与肿瘤临床病理特征显著相关,且化疗期间VEGF变化水平与近期化疗疗效密切相关。Objective To observe the changes in peripheral serum Vascular endothelial growth factor(VEGF)levels during chemotherapy in patients with esophageal squamous cell carcinoma(ESCC),and to explore its clinical significance Methods A total of 87 newly diagnosed ESCC patients by pathology examination from August 2018 to December 2019 were included in the test group,and 40 healthy volunteers receiving physical examinations during the same period were included in the control group.Peripheral VEGF levels between groups were compared.The correlation of peripheral VEGF levels with pathological data of ESCC patients was identified.A total of 62 patients in the test group received paclitaxel combined with cisplatin chemotherapy.The VEGF levels before and after chemotherapy were compared,and its correlation with clinical efficacy was analyzed.The receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of serum VEGF on ESCC.Results The peripheral serum VEGF level in the test group was significantly higher than that in the control group(P<0.05).The abnormally high serum VEGF level in ESCC patients was significantly correlated with disease progression(P<0.05).Serum VEGF level before chemotherapy was not correlated with the efficacy of chemotherapy(P>0.05).Serum VEGF level after chemotherapy in ESCC patients with an effective response to chemotherapy was significantly lower than that before chemotherapy(P<0.05).Serum VEGF level after chemotherapy in ESCC patients with an ineffective response to chemotherapy was significantly higher than that before chemotherapy(P<0.05).The area under the curve(AUC)of serum VEGF level in the diagnosis of ESCC was 0.863,and the optimal cut-off value was 229.74pg/ml.Conclusion VEGF is abnormally highly expressed in the peripheral serum of ESCC patients,which is significantly correlated with the clinicopathological characteristics of ESCC.Changes in serum VEGF levels during chemotherapy are closely correlated with the efficacy of recent chemotherapy.

关 键 词：食管鳞癌 血管内皮生长因子 化疗 化疗疗效 

分 类 号：R735.1[医药卫生—肿瘤]