重症急性胰腺炎并发急性呼吸窘迫综合征危险因素的Meta分析  

Meta-analysis of risk factors for severe acute pancreatitis complicated with acute respiratory distress syndrome

作　　者：王希望 屈浩然 雷阳 顾亚娇[2] 王晓[2] WANG Xiwang;QU Haoran;LEI Yang;GU Yajiao;WANG Xiao(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000;Department of Spleen,Stomach and Hepatobiliary,the First Affiliated Hospital of Henan University of Chinese Medicine,China)

机构地区：[1]河南中医药大学第一临床医学院,河南郑州450000 [2]河南中医药大学第一附属医院脾胃肝胆病科

出　　处：《胃肠病学和肝病学杂志》2023年第11期1271-1276,1282,共7页Chinese Journal of Gastroenterology and Hepatology

基　　金：河南省特色骨干学科中医学学科建设项目(STG-ZYX02-202116)。

摘　　要：目的系统分析重症急性胰腺炎患者发生急性呼吸窘迫综合征的危险因素。方法计算机检索PubMed、EmBase、Cochrane Library、Web of Science、中国知网、万方数据知识服务平台、维普和中国生物医学文献服务系统中关于重症急性胰腺炎患者发生急性呼吸窘迫综合征危险因素的文献,检索时限为建库至2022年11月。由两名研究者按照纳入及排除标准独立进行文献筛选、资料提取和质量评价后,采用Stata 16.0软件进行Meta分析。结果共纳入16篇文献,总病例数为2576例。Meta分析结果显示,APACHEⅡ、Ranson、CTSI评分高,PCT、CRP、血糖水平升高,ALB、血钙、氧合指数水平降低,呼吸频率、心率加快,合并腹腔间隔室综合征,感染,手术及ICU入住时间长是重症急性胰腺炎患者发生急性呼吸窘迫综合征的危险因素。结论临床医护人员应早期识别并干预发生急性呼吸窘迫综合征的高危因素,降低其发生率及死亡率。Objective To systematically analyze the risk factors of acute respiratory distress syndrome(ARDS)in severe acute pancreatitis(SAP).Methods Databases of PubMed,EmBase,Cochrane Library,Web of Science,CNKI,WanFang Data,CQVIP and SinoMed were searched for articles about the risk factors of ARDS in SAP from inception to Nov.2022.Two researchers independently performed literature screening according to inclusion and exclusion criteria,data extraction and methodological quality assessment.Stata 16.0 were employed for Meta-analysis.Results In total,16 studies were included,including 2576 patients.Meta-analysis demonstrated that higher APACHEⅡscore,Ranson score and CTSI score;increased CRP,PCT and blood glucose;lower ALB,blood calcium and oxygenation index;faster heart rate and respiratory rate;abdominal compartment syndrome,infection and surgery;long stay in the ICU were risk factors of ARDS in SAP.Conclusion Clinical medical workers should early identify and intervene SAP patients with the above-mentioned risks,so as to reduce the incidence of ARDS.

关 键 词：重症急性胰腺炎 急性呼吸窘迫综合征 危险因素 影响因素分析 META分析 

分 类 号：R576[医药卫生—消化系统]