原发性肝癌患者抑郁症状发生率的Meta分析  

Prevalence of Depressive Symptoms in Patients with Primary Liver Cancer:a Meta-analysis

作　　者：卢飞臣 游雪梅[2] 李繁荣 韦双双 杨莉洁 庞春华[3] 林景 赵凤娟[4] LU Feichen;YOU Xuemei;LI Fanrong;WEI Shuangshuang;YANG Lijie;PANG Chunhua;LIN Jin;ZHAO Fengjuan(Nursing College,Guangxi Medical University,Nanning 530021,China;Department of Nursing,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China;Department of Hepatobiliary Surgery,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China;Department of Head and Neck Surgery,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学护理学院,南宁530021 [2]广西医科大学附属肿瘤医院护理部,南宁530021 [3]广西医科大学附属肿瘤医院肝胆外科,南宁530021 [4]广西医科大学附属肿瘤医院头颈外科,南宁530021

出　　处：《神经损伤与功能重建》2023年第11期634-639,644,共7页Neural Injury and Functional Reconstruction

基　　金：国家自然科学基金项目(抑郁对肝癌微环境免疫抑制状态的正反馈作用机制,No.81960308);广西科技厅重点研发计划项目(基于心理资本理论的肿瘤医院护士工作倦怠预测模型构建及干预研究,桂科AB18126042)。

摘　　要：目的:系统评价国内外原发性肝癌(primary livercancer,PLC)患者抑郁症状的发生率。方法:计算机检索PubMed、Embase、The Cochrane Library、Web of Science、中国生物医学文献数据库、中国知网、万方数据库和维普数据库,收集关于国内外PLC患者抑郁症状发生率的文献,检索时限为建库至2022年4月。2名研究者独立筛选文献、提取资料并评价纳入文献的偏倚风险后,采用Stata 16.0软件进行Meta分析。结果:共纳入20篇文献。Meta分析结果显示,国内外PLC患者抑郁症状的发生率为47.1%(95%CI 38.7%~55.5%)。亚组分析结果显示,研究地域为国内、年龄<60岁、收入水平低、无工作、肿瘤分期为Ⅳ期、治疗前、筛查工具为HADS的患者抑郁症状发生率更高。结论:PLC患者抑郁症状的发生率较高。Objective:To systematically review the prevalence of depressive symptoms in patients with primary liver cancer(PLC)worldwide.Methods:PubMed,Embase,The Cochrane Library,Web of Science,China Biomedical Literature Database,CNKI,Wanfang database and VIP database were systematically searched to identify literature investigating the prevalence of depressive symptoms in PLC patients from the inception of these databases until April 2022.Two researchers independently screened the literature,extracted data,and evaluated the risk of bias in the included literature.Meta-analysis was performed using Stata 16.0 software.Results:A total of 20 literatures were included.Meta-analysis results showed that the prevalence of depressive symptoms in PLC patients was 47.1%(95%CI 38.7%~55.5%).The results of subgroup analysis showed that higher rates of depression were observed in patients with the following characteristics:Chinese,<60 years old,low income,unemployment,stageⅣtumor,no treatment and assessment using the HADS screening tool.Conclusion:PLC patients had a high prevalence of depressive symptoms.

关 键 词：肝脏肿瘤 抑郁 发生率 META分析 

分 类 号：R741[医药卫生—神经病学与精神病学] R749[医药卫生—临床医学]