宫颈癌中miRNA-409-3p、VEGF、Gab2表达与调强适形放疗同步化疗疗效及患者治疗后3年生存情况的关系  

Relationship between the expression of miRNA-409-3p,VEGF and Gab2 in cervical cancer and the efficacy of intensity-modulated conformal radiotherapy combined with chemotherapy and the 3-year survival of patients after treatment

作　　者：阿依努尔·色义提[1] 王一娜[1] 古丽娜·库尔班[1] 侯友翔[1] Ayinuer S;WANG Yi-na;Gulina K(Department of Gynecological Radiotherapy,Tumour Hospital Affiliated to Xinjiang Medical University,Urumqi Xinjiang 830011,China.)

机构地区：[1]新疆医科大学附属肿瘤医院妇科放射治疗科,新疆乌鲁木齐830011

出　　处：《临床和实验医学杂志》2023年第19期2061-2065,共5页Journal of Clinical and Experimental Medicine

基　　金：国家自然科学基金资助项目(编号:82260520)。

摘　　要：目的 探讨宫颈癌中微小RNA-409-3p(miRNA-409-3p)、血管内皮生长因子(VEGF)、Grb2协同结合蛋白2(Gab2)表达与调强适形放疗同步化疗疗效及治疗后3年生存情况的关系。方法 采用回顾性研究方法,选取2019年1月至2020年2月在新疆医科大学附属肿瘤医院治疗的宫颈癌患者138例,均给予调强适形放疗同步化疗。同时随访所有患者疗效及治疗后3年生存情况,分为化疗有效组(n=92)和治疗无效组(n=56)、死亡组(n=26)和存活组(n=112)。观察不同临床特征、疗效、预后患者宫颈癌组织miRNA-409-3p、VEGF、Gab2表达水平。结果 低分化宫颈癌组织miRNA-409-3p相对表达量明显低于中高分化宫颈癌组织,而VEGF mRNA和Gab2 mRNA相对表达量明显高于中高分化宫颈癌组织,差异均有统计学意义(P<0.05)。FIGO分期Ⅲ期宫颈癌组织miRNA-409-3p相对表达量明显低于Ⅱ期宫颈癌组织,而VEGF mRNA和Gab2 mRNA相对表达量明显高于Ⅱ期宫颈癌组织,差异均有统计学意义(P<0.05)。治疗有效组患者miRNA-409-3p相对表达量明显高于治疗无效组,而VEGF mRNA和Gab2 mRNA相对表达量明显高于治疗无效组,差异均有统计学意义(P<0.05)。死亡组患者miRNA-409-3p相对表达量明显高于存活组患者,而VEGF mRNA和Gab2 mRNA相对表达量明显高于存活组患者,差异均有统计学意义(P<0.05)。miRNA-409-3p、VEGF、Gab2表达预测疗效有效的ROC曲线下面积分别为0.647、0.779和0.616,预测价值较好(P<0.05)。miRNA-409-3p、VEGF、Gab2表达预测死亡的ROC曲线下面积分别为0.715、0.653和0.785,预测价值较好(P<0.05)。结论 宫颈癌组织miRNA-409-3p表达下调,而VEGF、Gab2表达上调,与调强适形放疗同步化疗疗效及预后有关,其中VEGF预测疗效有一定价值,而Gab2预测预后有一定价值。Objective To investigate the relationship between the expression of microRNA-409-3p(miRNA-409-3p),vascular endothelial growth factor(VEGF),and Grb2 co-binding protein 2(Gab2)in cervical cancer and the efficacy of intensity-modulated conformal radiotherapy combined with chemotherapy and 3-year survival after treatment.Methods Retrospective research methods was used,138 patients with cervical cancer who were treated in Xinjiang Medical University Affiliated Cancer Hospitalfrom January 2019 to February 2020 were selected,and all patients were treated with intensity-modulated conformal radiotherapy and concurrent chemotherapy.At the same time,all patients were followed up the efficacy and 3-year survival of all patients,and divide them into chemotherapy effective group(n=92)and ineffective group(n=56),death group(n=26),and survival group(n=112).And the differences in the expression of miRNA-409-3p,VEGF,and Gab2 in cervical cancer tissues of patients with patients with different clinical characteristics,efficacy,and prognosis were analyzed.Results The relative expression level of miRNA-409-3p in low-differentiated cervical cancer tissues was significantly lower than that in high-differentiated cervical cancer tissues,while the relative expression levels of VEGF mRNA and Gab2 mRNA were significantly higher than those of medium and highly differentiated cervical cancer,the differences were statistically significant(P<0.05).The relative expression level of miRNA-409-3p in FIGO stageⅢcervical cancer tissues was significantly lower than that in stageⅡcervical cancer tissues,the relative expression levels of VEGF mRNA and Gab2 mRNA were significantly higher than those of stageⅡcervical cancer tissue,the differences were statistically significant(P<0.05).The relative expression level of miRNA-409-3p in patients with effective treatment was significantly higher than that in patients with ineffective treatment,while the relative expression level of VEGF mRNA and Gab2 mRNA were significantly higher than those of ineffecti

关 键 词：宫颈癌 血管内皮生长因子 Grb2协同结合蛋白2 调强适形放疗同步化疗 临床疗效 预后 

分 类 号：R737.33[医药卫生—肿瘤] R730.55[医药卫生—临床医学]