环状RNA在缺血性脑卒中领域的研究进展  

Research progress of circular RNA in the field of ischemic stroke

作　　者：唐琛 兰瑞[2] 付雪琴 王玮玮[1] 邹旭欢 王漫漫[1] 李泓宇 刘双 TANG Chen;LAN Rui;FU Xueqin;WANG Weiwei;ZOU Xuhuan;WANG Manman;LI Hongyu;LIU Shuang(Henan University of Chinese Medicine,Zhengzhou 450000,China;the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000)

机构地区：[1]河南中医药大学,郑州450000 [2]河南中医药大学第一附属医院,郑州450000

出　　处：《中国比较医学杂志》2023年第10期100-105,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81973618,81503422);河南省中医药科学研究专项课题(2022JDZX090)。

摘　　要：环状RNA(circRNA)是一种非编码RNA,其3’和5’端连接在一起,构成了一种共价闭合的环状结构。缺血性脑卒中后,机体发生了包括氧化应激、线粒体功能障碍、炎症、内质网应激、细胞凋亡和自噬在内的多种病理生理机制。circRNA主要通过海绵吸附微小RNA(microRNA),调节缺血性脑卒中相关基因表达水平,参与脑卒中的调控。在缺血性脑卒中发生后,部分circRNA对大脑发挥保护作用,而另一些circRNA则对大脑有损害作用。研究表明circRNA很有潜力在未来为缺血性脑卒中提供新的诊疗方法。本文就circRNA在缺血性脑卒中领域的研究进展进行综述,并对circRNA的未来应用进行展望。Circular RNA(circRNA)is a type of non-coding RNA,in which 3’and 5’ends are joined together to form a covalently closed circular structure.Following ischemic stroke,the body undergoes various pathophysiological mechanisms,including oxidative stress,mitochondrial dysfunction,inflammation,endoplasmic reticulum stress,apoptosis,and autophagy.CircRNAs are involved in regulation of stroke by regulating the expression levels of ischemic stroke-related genes,mainly through sponge-adsorbed microRNAs.After ischemic stroke,some circRNAs have a protective effect on the brain,while others have a damaging effect on the brain.Studies suggest that circRNAs have the potential to provide new therapeutic approaches for ischemic stroke in the future.This article reviews the progress of circRNA research in the field of ischemic stroke and provides an outlook on the future applications of circRNAs.

关 键 词：circRNA 缺血性脑卒中 microRNA海绵 

分 类 号：R-33[医药卫生]