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作 者:邢海艳 李超 鲁素雅 刘洋[1] XING Haiyan;LI Chao;LU Suya;LIU yang(Huai'an Institute for food and drug control,Huai'an 223005,China;Asymchem Life Science(Tianjin)Co.,Ltd.,Tianjin 300457,China)
机构地区:[1]淮安市食品药品检验所,江苏淮安223005 [2]凯莱英生命科学技术(天津)有限公司,天津300457
出 处:《化学分析计量》2023年第11期72-77,共6页Chemical Analysis And Meterage
摘 要:建立高效液相色谱-串联质谱法同时测定婴幼儿化妆品中卡松和对羟基苯甲酸酯类等12种防腐剂。样品经甲醇溶解,超声提取,使用飞诺美Kinetex^(?)C_(18)(100 mm×2.1 mm,1.7μm)色谱柱,用0.1%甲酸溶液-乙腈为流动相进行梯度洗脱,在电喷雾离子源正负离子多反应监测模式下同时检测。12种防腐剂的质量浓度在1~100 ng/mL范围内与对应的色谱峰面积线性关系良好,相关系数为0.997~0.999 6,检出限为0.01~0.12μg/g,定量限为0.02~0.40μg/g。膏霜类样品基质效应较小,可不予考虑。样品在0.625、1.25、6.25μg/g 3个加标水平时的平均回收率为72.97%~106.53%,测定结果的相对标准偏差为1.13%~9.67%(n=6)。该方法简单、灵敏,可用于不同类型婴幼儿化妆品中卡松和对羟基苯甲酸酯类等12种防腐剂的测定。A method was established for simultaneous determining of 12 preservatives including kathon and p-hydroxybenzoic acid ester in infant cosmetics by liquid chromatography tandem mass spectrometry.The sample was dissolved in methanol,extracted by ultrasound.Phenomenex Kinetex~? C_(18)(100 mm×2.1 mm,1.7 μm) chromatographic column was used for gradient elution with 0.1% formic acid solution and acetonitrile as mobile phase,and simultaneously detection under the positive and negative ion multi reaction monitoring mode of electric spray ion source.The mass concentration of 12 preservatives had a good linear relationship with the corresponding peak area in the range of 1-100ng/mL,with the correlation coefficients of 0.997-0.999 6.The detection limits were 0.01-0.12 μg/g,and the quantification limits were 0.02-0.40 μg/g.The method had a relatively small matrix effect on cream samples.The average recoveries of standard addition at three different levels of 0.625,1.25,6.25 μg/g were 72.97%-106.53%,and the relative standard deviations were 1.13%-9.67%(n=6).This method is simple and sensitive,which can be used for the determination of 12preservatives including kathon and p-hydroxybenzoate in different types of infant cosmetics.
关 键 词:高效液相色谱-串联质谱法 卡松 对羟基苯甲酸酯类化合物 防腐剂 婴幼儿化妆品
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