溶酶体相关性癫癎的研究进展  

Research Progress of Lysosomal Associated Epilepsy

作　　者：李静文 张黎明[1] LI Jing-wen;ZHANG Li-ming(Department of Neurology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,哈尔滨150001

出　　处：《中国临床神经科学》2023年第5期582-587,共6页Chinese Journal of Clinical Neurosciences

摘　　要：溶酶体是细胞内常见的膜性结构细胞器,在维持细胞稳态等方面发挥着重要作用。近年来,国内外对癫间发病机制的研究有了新进展,线粒体、过氧化物酶体、溶酶体等一系列细胞器在癫癎的发生发展中起着关键作用。其中,溶酶体成为近年来的研究热点,大量研究表明,溶酶体功能障碍与进行性肌阵挛性癫癎、Ohtahara综合征、Lennox-Gastaut综合征、West综合征以及结节性硬化症密切相关。因而,文中对溶酶体相关性癫癎的研究进展进行综述。Lysosomes are common membranous organelles in cells,which play an important role in maintaining cell homeostasis.A series of organelles,such as mitochondria,peroxisome and lysosomes,play a key role in the development of epilepsy in the study of the pathogenesis of epilepsy.Lysosome has become a research hotspot in recent years.A large number of studies have shown that lysosomal dysfunction is closely related to progressive myoclonic epilepsy,Ohtahara syndrome,Lennox-Gastaut syndrome,West syndrome and tuberous sclerosis.The research progress of lysosomal related epilepsy wsa reviewed.

关 键 词：癫癎 溶酶体 雷帕霉素靶蛋白 氯离子通道 

分 类 号：R742.1[医药卫生—神经病学与精神病学]