非人灵长类动物黄斑疾病模型的研究进展  

Recent advances in nonhuman primate models of macular diseases

作　　者：何海龙 金子兵 He Hailong;Jin Zibing(Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100005,China)

机构地区：[1]北京市眼科研究所、北京同仁眼科中心、首都医科大学附属北京同仁医院、北京市眼科学与视觉科学重点实验室,北京100005

出　　处：《中华眼底病杂志》2023年第11期953-958,共6页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金杰出青年科学基金(82125007)

摘　　要：黄斑区是形成空间视力和色觉的关键解剖结构,黄斑疾病严重威胁患者的视觉功能及生活质量。非人灵长类动物(NHP)是唯一拥有类似人类黄斑结构的哺乳动物,因此在研究黄斑疾病方面具有重要价值。目前,多种方法包括自发性、基因编辑、药物诱导、光诱导及机械性损伤等,可用于筛选和构建NHP模型,用于研究眼皮肤白化病、全色盲、视网膜色素变性、老年性黄斑变性及一些罕见的眼部综合征。在构建NHP模型时,应充分考虑其他动物模型,以实现模型之间的互补研究。此外,应充分发挥NHP的资源优势,创建具有可控遗传背景的灵长类品系,有助于早日实现可持续利用的目标。The macula is a critical anatomical structure for primates to acquire high-resolution spatial and color vision,with macula lesions posing a significant threat to patients'visual function and quality of life.Non-human primate(NHP)are the only mammals with a macular structure that is closest to that of humans,thus offering substantial value in the study of macular diseases.Currently,various methods,including spontaneous occurrence,gene editing,drug-induced,light-induced,and mechanical injury,can be employed to screen and establish NHP models for investigating conditions such as oculocutaneous albinism,achromatopsia,retinitis pigmentosa,age-related macular degeneration,and certain rare ocular syndromes.When constructing NHP models,due consideration should be given to other animal models to facilitate complementary research across different model systems.Additionally,leveraging the advantages of NHP and establishing genetically controlled NHP strains is a goal to strive for to achieve sustainable utilization of these resources in research.

关 键 词：非人灵长类动物 动物模型 黄斑疾病 综述 

分 类 号：R774.5[医药卫生—眼科]