补体在癫痫发病机制及靶向治疗中的研究进展  

Advances of complement in the pathogenesis and targeted therapy of epilepsy

作　　者：胡春辉 林滨榕[1] 周有峰 HU Chunhui;LIN Binrong;ZHOU Youfeng(Department of Neurology,Fujian Children's Hospital(Fujian Branch of Shanghai Children's Medical Center),National Regional Medical Center,College of Clinical Medicine for Obstetrics&Gynecology and Pediatrics,Fujian Medical University,Fuzhou 350014,China)

机构地区：[1]福建医科大学妇儿临床医学院·国家区域医疗中心·福建省儿童医院(上海儿童医学中心福建医院)神经内科,福州350014

出　　处：《癫痫杂志》2023年第6期492-497,共6页Journal of Epilepsy

摘　　要：全世界有超过6500万癫痫患者,癫痫致残率、致死率高,且疾病带来的社会负担和心理负担严重。癫痫病因复杂,发作形式多种多样,临床表现和病因学均存在很大的异质性。目前癫痫病因分为六大类:结构性、遗传性、感染性、代谢性、免疫性和神经退行性。癫痫免疫性病因越来越受到重视,其中补体作为免疫系统的重要组成部分,能够通过促进炎症反应、影响突触缺失及修剪失衡、形成膜攻击复合体等参与癫痫发生发展,在癫痫发病机制中起着重要作用。静脉注射免疫球蛋白、人源性C1酯酶抑制剂、单克隆抗体Eculizumab/Ravulizumab,已在癫痫中被用于补体靶向治疗。但癫痫与免疫的关系复杂,揭示补体在癫痫发生、发展及治疗中的作用,仍有待于进一步深入研究。There are more than 65 million patients with epilepsy in the world.The morbidity and mortality of epilepsy are high,and the social and psychological burden brought by this disease is serious.The etiology of epilepsy is complex and the seizure types are various.There are great heterogeneity in the clinical manifestations and etiology.At present,the etiology of epilepsy can be classified as six categories:structural,genetic,infectious,metabolic,immune,and neurodegenerative.More and more attention has been paid to the immune etiology of epilepsy.Complement,as an important part of the immune system,can participate in the development of epilepsy by promoting inflammatory response,affecting synaptic deletion and pruning imbalance,forming membrane attack complex and so on,which plays an important role in the pathogenesis of epilepsy.Intravenous immunoglobulin,human C1 esterase inhibitor(C1-Inh)and monoclonal antibody Eculizumab/Ravulizumab have been used for complement targeted therapy in epilepsy.However,the relationship between epilepsy and immunity is complex,and the role of complement in the epileptogenesis,development and treatment of epilepsy still needs to be further studied.

关 键 词：癫痫 补体 机制 治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学]