入院白蛋白、T淋巴细胞亚群、白细胞计数预测中晚期宫颈癌化疗患者医院感染的价值  

Values of albumin,T lymphocyte subsets and leukocyte count on admission in predicting nosocomial infection in patients with advanced cervical cancer undergoing chemotherapy

作　　者：郭娟 薛娇 熊沫 董婕 GUO Juan;XUE Jiao;XIONG Mo(Department of Oncology,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan Hubei 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤科,湖北武汉430030

出　　处：《临床和实验医学杂志》2023年第20期2185-2189,共5页Journal of Clinical and Experimental Medicine

基　　金：湖北省卫生健康委面上项目(编号:WJ2021M118)。

摘　　要：目的分析入院白蛋白、T淋巴细胞亚群、白细胞计数(WBC)预测中晚期宫颈癌化疗患者医院感染的价值。方法选取2020年1月至2022年1月在华中科技大学同济医学院附属同济医院肿瘤科住院接受化疗治疗的187例中晚期宫颈癌患者作为研究对象,对其入院时血常规指标、血液生化指标、外周血T淋巴细胞亚群指标及医院感染情况进行回顾性分析。结果有66例患者发生医院感染,感染率为35.29%,感染部位以泌尿系统为主,占53.03%,其次为呼吸系统,占22.73%。感染组患者入院WBC、白蛋白、CD4^(+)T淋巴细胞比例、CD4^(+)/CD8^(+)T淋巴细胞比值分别为(4.19±1.75)×10^(9)/L、(35.80±3.70)g/L、(31.49±2.78)%、1.01±0.16,均低于未感染组[(6.00±2.01)×10^(9)/L、(41.72±5.02)g/L、(35.13±2.83)%、1.44±0.29],差异均有统计学意义(P<0.05)。WBC、白蛋白、CD4^(+)T淋巴细胞比例、CD4^(+)/CD8^(+)T淋巴细胞比值预测中晚期宫颈癌化疗患者医院感染的受试者工作特征曲线下面积(AUC)分别为0.742、0.815、0.806、0.896,在截断值下,CD4^(+)T淋巴细胞比例的敏感度最高,WBC的特异度最高。结论中晚期宫颈癌的医院感染部位以泌尿系统为主,患者入院WBC、白蛋白、CD4^(+)T淋巴细胞比例、CD4^(+)/CD8^(+)T淋巴细胞比值的下降可提示其医院感染风险,临床医师应对患者开展综合性的治疗前评价并采取有效的干预措施,以降低其医院感染发生率。Objective To analyze the values of albumin,T lymphocyte subsets and white blood cell count(WBC)on admission in predicting nosocomial infection in patients with advanced cervical cancer after chemotherapy.Methods A total of 187 patients with advanced cervical cancer hospitalized in Department of Oncology,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology from January 2020 to January 2022 were selected as the research subjects.The blood routine indexes,blood biochemical indexes,peripheral blood T lymphocyte subsets on admission and nosocomial infections were analyzed retrospectively.Results Sixity-six patients had nosocomial infection,the infection rate was 35.29%,the infection site was mainly urinary system,accounting for 53.03%,followed by respiratory system,accounting for 22.73%.The WBC,ALB,CD4^(+)T lymphocytes percentage and CD4^(+)/CD8^(+)T lymphocytes ratio of the patients in the infection group were(4.19±1.75)×10^(9)/L,(35.80±3.70)g/L,(31.49±2.78)%and 1.01±0.16,respectively,which were lower than those in the uninfected group[(6.00±2.01)×10^(9)/L,(41.72±5.02)g/L,(35.13±2.83)%,1.44±0.29],the differences were statistically significant(P<0.05).The areas under receiver operating characteristic area under the curve(AUC)of WBC,ALB,CD4^(+)T lymphocytes percentage and CD4^(+)/CD8^(+)T lymphocytes ratio in prediction of nosocomial infection of patients with advanced cervical cancer undergoing chemotherapy were 0.742,0.815,0.806 and 0.896 respectively.Under the cut-off value,the sensitivity of CD4^(+)T lymphocytes percentage was the highest,and the specificity of WBC was the highest.Conclusion The nosocomal infection sites were mainly urinary system in the patients with advanced cervical cancer undergoing chemotherapy.The decreases of WBC,ALB,CD4^(+)T lymphocytes percentage and CD4^(+)/CD8^(+)T lymphocyte ratio on admission in the patients can indicate the risk of nosocomial infection.Clinicians should carry out comprehensive pre-treatment evaluation and take effective int

关 键 词：白蛋白 T淋巴细胞亚群 白细胞计数 中晚期宫颈癌 化疗 医院感染 

分 类 号：R737.33[医药卫生—肿瘤]