肿瘤标志物PIVKA-Ⅱ、AFP联合纤溶二项DD、FDP检测在原发性肝癌诊断中的应用价值研究  

Study on application value of tumor markers of protein induced by vitamin K absence or antagonist-Ⅱ,alpha-fetoprotein combined with D-dimer and fibrin(ogen)degradation products in diagnosis of primary liver cancer

作　　者：黄建芳 王怡 陈怡 郭瑞德 周剑 陈雪莱 HUANG Jian-fang;WANG Yi;CHEN Yi;GUO Rui-de;ZHOU Jian;CHEN Xue-lai(Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Zhejiang 325000,China;不详)

机构地区：[1]温州市中西医结合医院,浙江325000 [2]温州医科大学附属第一医院

出　　处：《中国卫生检验杂志》2023年第20期2520-2523,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血清肿瘤标志物异常凝血酶原(PIVKA-Ⅱ)、甲胎蛋白(AFP)联合纤溶二项D-二聚体(DD)、纤维蛋白原降解产物(FDP)检测在原发性肝癌(PLC)诊断中的应用价值。方法选取2020年1月—2022年12月温州市中西医结合医院收治的患者及部分温州医科大附属第一医院收治的患者为研究对象,其中40例原发性肝癌(PLC)患者,40例肝硬化(LC)患者,40例健康体检人员(HC);比较3组患者血清PIVKA-Ⅱ、AFP、DD、FDP水平,并绘制受试者工作曲线(ROC),分析PIVKA-Ⅱ、AFP指标以及纤溶二项DD、FDP检测在PLC诊断中的价值。结果PLC组血清肿瘤标志物PIVKA-I、AFP水平显著高于LC组和健康组(P<0.05),PLC组血清纤溶二项DD、FDP水平显著高于LC组和健康组(P<0.05);ROC曲线结果显示,PIVKA-Ⅱ、AFP指标检测的AUC分别为0.935、0.902,DD、FDP指标检测的AUC值分别为0.792、0.827,其中PIVKA-Ⅱ检测对肝癌的诊断价值最高。结论肿瘤标志物PIVKA-Ⅱ检测在PLC诊断中具有较高的诊断价值,与AFP、DD、FDP检查联合能够显著的区分肝癌和肝硬化患者,有利于肝癌患者的早期诊断。Objective This paper aims to explore the value of serum tumor markers of protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-II),alpha-fetoprotein(AFP)combined with D-dimer(DD)and fibrin(ogen)degradation products(FDP)in the diagnosis of primary liver cancer(PLC).Methods The patients hospitalized in Wenzhou Integrated Traditional Chinese and Western Medicine Hospital and the First Affiliated Hospital of Wenzhou Medical University from January 2020 to December 2022 were collected into this study,including 40 patients with PLC,40 patients with liver cirrhosis(LC)and 40 healthy controls(HC).The serum levels of PIVKA-II,AFP,DD and FDP were detected among the three groups,and the receiver working curve(ROC)was drawn to analyze the diagnostic value of PIVKA-II,AFP and fibrinolysis DD and FDP in PLC.Results The levels of serum tumor markers,PIVKA-II and AFP in PLC were higher than those in LC and HC(P<0.05),and the levels of serum fibrinolytic DD and FDP in PLC were higher than those in LC and HC(P<0.05).The results of ROC curve showed that the AUC of PIVKA-II and AFP was 0.935 and 0.902,respectively,and the AUC value of DD and FDP was 0.792 and 0.827,among which PIVKA-II had the highest diagnostic value for liver cancer.Conclusion The detection of PIVKA-II has a high diagnostic value in the diagnosis of PLC.Combined with AFP,DD and FDP,it can significantly distinguish patients with liver cancer and cirrhosis,which is conducive to the early diagnosis of liver cancer patients.

关 键 词：原发性肝癌 异常凝血酶原 甲胎蛋白 D-二聚体 纤维蛋白(原)降解产物 

分 类 号：R735.7[医药卫生—肿瘤]