术前铁代谢异常对卵巢癌患者腹腔镜根治性切除术后复发的影响  

Impact of preoperative abnormal iron metabolism on recurrence among ovarian cancer patients undergoing laparoscopic radical resection

作　　者：黄华龙 Huang Hualong(Department of Obstetrics and Gynecology,Anyang Maternal and Child Health Care Hospital,Anyang,Henan 455000,China)

机构地区：[1]安阳市妇幼保健院妇产科,河南安阳455000

出　　处：《齐齐哈尔医学院学报》2023年第17期1641-1644,共4页Journal of Qiqihar Medical University

摘　　要：目的探究术前铁代谢异常对卵巢癌患者腹腔镜根治性切除术后复发的影响。方法前瞻性纳入2019年6月—2020年6月本院妇科收治的卵巢癌患者120例作为研究对象,所有患者入院后均接受腹腔镜根治性切除术,根据术后2年内患者的复发情况将其分为发生组(43例)与未发生组(77例)。收集所有卵巢癌患者的临床资料,比较患者术前铁代谢情况,探究术前铁代谢异常对卵巢癌患者腹腔镜根治性切除术后复发的影响。结果120例卵巢癌患者中,术后复发占比35.83%,术后未复发占比64.17%;发生组与未发生组在肿瘤分期、组织学类型比较,差异有统计学意义(P<0.05);两组其他方面比较,差异无统计学意义(P>0.05);发生组的铁蛋白(SF)水平高于未发生组,血清铁(SI)和血清总铁结合力(TIBC)水平低于未发生组,差异有统计学意义(P<0.05);经过Logistic回归因素分析可以得出,肿瘤分期、组学类型、术前铁代谢指标与卵巢癌患者术后复发有关(P<0.05)。结论腹腔镜根治性切除术后卵巢癌患者复发的因素可能与肿瘤分期、组织学类型、术前铁代谢指标有关,而术前铁代谢指标异常明显的患者术后发生复发的风险更高。Objective To investigate the impact of preoperative abnormal iron metabolism on recurrence among ovarian cancer patients undergoing laparoscopic radical resection.Methods The patients with ovarian cancer admitted to the Department of Obstetrics and Gynecology,Anyang Maternal and Child Health Care Hospital from June 2019 to June 2020 were prospectively included as the study subjects.All patients received laparoscopic radical resection after admission.According to the recurrence of patients within 2 years after surgery,they were divided into the occurrence group(n=43)and the non occurrence group(n=77).The clinical data of all patients with ovarian cancer were collected to compare the preoperative iron metabolism and explore the impact of abnormal iron metabolism on the recurrence of patients with ovarian cancer after laparoscopic radical resection.Results Among the 120 patients with ovarian cancer,35.83%of them suffering postoperative recurrence and 64.17%had no postoperative recurrence.There was a statistical significant difference in tumor stage and histological type between the occurrence group and the non occurrence group(P<0.05).There were no statistical significant difference between the two groups in other aspects(P>0.05).The level of ferritin(SF)in the occurrence group was higher than that in the non occurrence group,and the levels of serum iron(SI)and total iron binding capacity(TIBC)were lower than those in the non occurrence group,with a statistical significant difference(P<0.05).Logistic regression analysis showed that tumor stage,histological type,preoperative iron metabolism indicators were related to postoperative recurrence of patients with ovarian cancer(P<0.05).Conclusions The recurrence among patients with ovarian cancer undergoing laparoscopic radical resection may be related to tumor stage,histological type and preoperative iron metabolism indicators.Patients with significant preoperative iron metabolism indicators have a higher risk of recurrence.

关 键 词：卵巢癌 腹腔镜根治性切除术 铁代谢 术后复发 

分 类 号：R737.31[医药卫生—肿瘤]