内镜下纤维蛋白黏合剂喷涂联合卡络磺钠治疗消化性溃疡出血的效果  

Therapeutic Effect of Endoscopic Fibrin Adhesive Spray Combined with Carbazochrome Sodium Sulfonate in the Treatment of Peptic Ulcer Bleeding

作　　者：侯保全 HOU Baoquan(Department of Gastroenterology,Changzheng People’s Hospital,Shangqiu 476000,China)

机构地区：[1]商丘市长征人民医院消化内科,河南商丘476000

出　　处：《河南医学研究》2023年第21期3947-3951,共5页Henan Medical Research

摘　　要：目的观察内镜下纤维蛋白黏合剂喷涂联合卡络磺钠治疗消化性溃疡出血的临床效果。方法采用前瞻性随机对照研究方法,选取2019年1月至2022年12月商丘市长征人民医院收治的70例消化性溃疡出血患者作为研究对象,采用随机数字表法分为观察组(35例)与对照组(35例)。对照组接受内镜下喷涂纤维蛋白黏合剂治疗,观察组在对照组基础上加用卡络磺钠冲洗治疗。比较两组患者围手术期指标、凝血功能、临床观察指标、术后并发症以及再出血率(内镜治疗后3个月内)。结果治疗后,观察组首次止血成功率高于对照组,大便潜血试验转阴、呕血停止时间较对照组更短(P<0.05);但两组患者手术时间比较,差异无统计学意义(P>0.05)。观察组活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)较对照组更短,纤维蛋白原(FIB)水平较对照组更高(P<0.05)。观察组血红蛋白(HGB)、血小板(PLT)较对照组更高(P<0.05)。两组患者均出现并发症,但组间差异无统计学意义(P>0.05)。观察组再出血率低于对照组,差异有统计学意义(P<0.05)。结论内镜下纤维蛋白黏合剂喷涂联合卡络磺钠可有效治疗消化性溃疡出血,提高首次止血成功率,改善围手术期、临床观察指标以及凝血功能,还能降低再出血率。Objective To observe the clinical efficacy of endoscopic fibrin adhesive spray combined with carbazochrome sodium sulfonate in the treatment of peptic ulcer bleeding.Methods A prospective randomized controlled study was conducted to select 70 patients with peptic ulcer bleeding admitted to Changzheng People’s Hospital in Shangqiu City from January 2019 to December 2022 as the study subjects.They were divided into observation group(35 cases)and control group(35 cases)by random number method.The control group was treated with endoscopic fibrin adhesive spray,while the observation group was treated with carbazochrome sodium sulfonate irrigation on top of the control group.The perioperative indexes,coagulation function,clinical observation indexes,postoperative complications and rebleeding rate(within 3 months after endoscopic treatment)were compared between the two groups.Results After treatment,the success rate of first hemostasis in the observation group was higher than that in the control group,and the time of stool occult blood test turning negative and hematemesis stopping was shorter than that in the control group(P<0.05).But there was no difference in the operation time between the two groups(P>0.05).The activated partial prothrombin time(APTT)and prothrombin time(PT)in the observation group were shorter than those in the control group,and the fibrinogen(FIB)level was higher than that in the control group(P<0.05).The hemoglobin(HGB)and platelet(PLT)in the observation group were higher than those in the control group(P<0.05).Complications occurred in both groups,but there was no difference between the two groups(P>0.05).The rebleeding rate in the observation group was lower than that in the control group(P<0.05).Conclusion Endoscopic fibrin adhesive spray combined with carbazochrome sodium sulfonate can effectively treat peptic ulcer bleeding,increase the success rate of first hemostasis,improve perioperative,clinical observation indicators,and coagulation function,and also reduce the rate of rebleeding.

关 键 词：消化性溃疡出血 内镜 纤维蛋白黏合剂 卡络磺钠 凝血功能 

分 类 号：R573.1[医药卫生—消化系统]