宫颈癌组织中KRT17 KLF4表达与其临床病理特征及患者预后的相关性  

Correlation between KRT17 and KLF4 Expression in Cervical Cancer Tissue and Patient Prognosis

作　　者：常畅[1] 高静 李志强[1] CHANG Chang;GAO Jing;LI Zhiqiang(The Second Hospital Affiliated to Hebei North College,Hebei Zhangjiakou 075100,China)

机构地区：[1]河北北方学院附属第二医院病理科,河北张家口075100

出　　处：《河北医学》2023年第11期1811-1816,共6页Hebei Medicine

基　　金：河北省张家口市重点研发计划项目,(编号:2221042D)。

摘　　要：目的:宫颈癌(CC)组织角蛋白17(KRT17)、Kruppel样因子4(KLF4)表达与患者预后的相关性。方法:选取2015年4月至2019年4月在我院妇产科确诊为CC的86例患者为研究对象,取其癌组织和癌旁组织为CC组和癌旁组。采用免疫组化法检测KRT17、KLF4的表达情况;利用Kaplan-Meier法分析KRT17、KLF4与CC患者预后的关系;COX回归分析影响CC患者预后的危险因素。结果:与癌旁组相比,CC组KRT17的阳性表达率显著升高,KLF4阳性表达率显著降低(P<0.05)。KRT17和KLF4表达水平与肌层浸润深度、淋巴结转移、分化程度有关(P<0.05)。Kaplan-Meier法分析结果表明,KRT17阳性表达组患者3年内累积生存率低于阴性表达组,KLF4阳性表达组患者3年内累积生存率高于阴性表达组(P<0.05)。多因素COX回归分析,结果显示,肌层浸润深度、淋巴结转移、KRT17和KLF4表达是影响CC患者预后的危险因素(P<0.05)。结论:CC组KRT17的阳性表达率显著升高,KLF4阳性表达率显著降低,与临床病理特征存在密切关系,对CC患者的预后有一定的评估价值。Objective:To investigate the correlation between the expression of Keratin 17(KRT17)and Kruppel-like factor 4(KLF4)in cervical cancer(CC)tissue and the prognosis of patients.Methods:From April 2015 to April 2019,86 patients diagnosed with CC in the Department of Obstetrics and Gynecology at our hospital were included in this study.Tissue samples were collected from the cancerous areas(CC group)and adjacent non-cancerous areas(adjacent group).The expressions of KRT17 and KLF4 were assessed using immunohistochemistry.Kaplan-Meier analysis was employed to examine the relationship between KRT17,KLF4 expression,and the prognosis of CC patients.Additionally,COX regression analysis was conducted to identify risk factors influencing the prognosis of CC patients.Results:In comparison to the adjacent group,the CC group exhibited a significantly higher rate of positive KRT17 expression and a notably lower rate of positive KLF4 expression(P<0.05).The expression levels of KRT17 and KLF4 were found to be associated with the depth of myometrial invasion,lymph node metastasis,and the degree of differentiation(P<0.05).Kaplan-Meier analysis revealed that within the KRT17 high-expression group,patients had a lower 3-year cumulative survival rate compared to the low-expression group.Conversely,the 3-year cumulative survival rate in the KLF4 high-expression group was higher than in the low-expression group(P<0.05).Multivariate COX regression analysis demonstrated that myometrial invasion depth,lymph node metastasis,KRT17,and KLF4 expression were significant risk factors affecting the prognosis of CC patients(P<0.05).Conclusion:In the CC group,there was a significant increase in the rate of positive KRT17 expression and a significant decrease in the rate of positive KLF4 expression.These findings are closely related to clinicopathological characteristics and hold valuable implications for evaluating the prognosis of CC patients.

关 键 词：宫颈癌 角蛋白17 Kruppel样因子4 预后 

分 类 号：R737.33[医药卫生—肿瘤]