RDW hs-CRP凝血纤溶指标与缺血性脑卒中患者脑动脉狭窄的相关性分析  

Correlation Analysis of RDW hs-CRP and Coagulation-Fibrinolysis Index with Cerebral Artery Stenosis in Ischemic Stroke Patients

作　　者：陈竹[1] 李冲[1] 王新星 马莉[1] 张兰樱 CHEN Zhu;LI Chong;WANG Xinxing(Luzhou People's Hospital,Sichuan Luzhou 646000,China)

机构地区：[1]四川省泸州市人民医院,四川泸州646000

出　　处：《河北医学》2023年第11期1864-1868,共5页Hebei Medicine

基　　金：四川省卫生和计划生育委员会科研课题,(编号:17PJ091)。

摘　　要：目的:分析红细胞分布宽度(RDW)、超敏C反应蛋白(hs-CRP)和凝血纤溶指标与缺血性脑卒中患者脑动脉狭窄的相关性。方法:选取2019年1月至2021年5月我院收治的126例缺血性脑卒中患者,根据是否存在脑动脉狭窄现象分为脑动脉狭窄组57例和脑动脉正常组69例。比较两组患者RDW、超敏C反应蛋白(hs-CRP)和凝血纤溶指标,并分析它们之间的相关性。结果:两组患者高血压病史差异有统计学意义(P<0.05);脑动脉狭窄组患者红细胞分布宽度(RDW)明显大于脑动脉正常组(P<0.05),hs-CRP明显高于脑动脉正常组,差异有统计学意义(P<0.05);脑动脉狭窄组患者活化部分凝血活酶时间(APTT)明显低于脑动脉正常组患者(P<0.05),纤维蛋白原(FIB)、D-二聚体(D-D)水平明显高于脑动脉正常组患者(P<0.05);Pearson或Spearman相关性分析结果显示,RDW、FIB、D-D、hs-CRP与脑动脉狭窄呈显著正相关(P<0.05),APTT与脑动脉狭窄呈显著负相关(P<0.05)。结论:RDW、hs-CRP、凝血纤溶指标与缺血性脑卒中患者脑动脉狭窄存在一定的相关性。Objective:To analyze the correlation between Red Blood Cell Distribution Width(RDW),high-sensitivity C-reactive protein(hs-CRP),and coagulation-fibrinolysis index with cerebral artery stenosis in patients suffering from ischemic stroke.Methods:A total of 126 patients with cerebral arterial thrombosis admitted to our hospital between January 2019 and May 2021 were included.They were categorized into two groups:the cerebral arterial stenosis group(n=57)and the cerebral arterial normal group(n=69)based on the presence of cerebral artery stenosis.Comparative analysis of RDW,high-sensitivity C-reactive protein(hs-CRP),and coagulation-fibrinolysis index was performed between the two groups,and their correlations were examined.Results:Significant differences were observed in the history of hypertension between the two groups of patients(P<0.05).In the cerebral arterial stenosis group,patients exhibited significantly larger red blood cell distribution width(RDW)values in the neck region compared to the cerebral arterial normal group(P<0.05).Additionally,hs-CRP levels in the cerebral arterial stenosis group were notably higher than those in the cerebral arterial normal group,with statistically significant differences(P<0.05).Furthermore,patients in the cerebral arterial stenosis group had significantly lower levels of activated partial thromboplastin time(APTT)compared to patients in the cerebral arterial normal group(P<0.05).In contrast,fibrinogen(FIB)and D-dimer(D-D)levels in the cerebral arterial stenosis group were significantly higher than those in the cerebral arterial normal group(P<0.05).Pearson or spearman correlation analysis results demonstrated a significant positive correlation between RDW,FIB,D-D,hs-CRP,and cerebral artery stenosis(P<0.05).However,APTT showed a significant negative correlation with cerebral artery stenosis(P<0.05).Conclusion:The findings suggest that RDW,hs-CRP,and coagulation-fibrinolysis index are indeed correlated with cerebral artery stenosis in patients with cerebral arterial thrombosis

关 键 词：红细胞分布宽度 HS-CRP 凝血纤溶指标 缺血性脑卒中 脑动脉狭窄 

分 类 号：R743.3[医药卫生—神经病学与精神病学]