调强放疗同期联合5-氟尿嘧啶与奥沙利铂对局部晚期鼻咽癌患者的疗效及安全性分析  

Efficacy and safety analysis of intensity modulated radiotherapy combined with 5-fluorouracil and oxaliplatin in patients with locally advanced nasopharyngeal carcinoma

作　　者：李言冰 李子俊 马丁丁 左宏波 王志[1] LI Yanbing;LI Zijun;MADingding;ZUO Hongbo;WANG Zhi(the Second Department of Cancer,Jiujiang First People's Hospital,Jiangxi,Jiujiang,332000,China)

机构地区：[1]九江市第一人民医院肿瘤二科,江西九江332000

出　　处：《当代医学》2023年第24期112-114,共3页Contemporary Medicine

基　　金：江西省卫生健康委科技计划项目(SKJP120201751)。

摘　　要：目的探讨调强放疗同期联合5-氟尿嘧啶(5-FU)与奥沙利铂对局部晚期鼻咽癌患者的临床疗效及安全性。方法选取2019年1月至2020年12月于本院进行治疗的66例局部晚期鼻咽癌患者作为研究对象,以其入院单双数法编号分为对照组与观察组,每组33例。两组均接受根治性同期调强放疗并于使用5-FU静脉滴注治疗,对照组在以上治疗基础上配合顺铂静脉滴注,观察组配合奥沙利铂静脉滴注治疗。比较两组近期疗效、6个月生存率、复发率、肿瘤远处转移率、治疗期间不良反应发生情况。结果两组近期治疗总有效率比较差异无统计学意义;两组6个月生存率、复发率及肿瘤远处转移率比较差异无统计学意义。观察组治疗期间不良反应发生率为21.21%,低于对照组的45.45%,差异有统计学意义(P<0.05)。结论调强放疗期间联合5-FU、奥沙利铂与5-FU、顺铂化疗治疗局部晚期鼻咽癌患者疗效相当,其中奥沙利铂辅助化疗的药物毒性较弱。Objective To investigate the clinical efficacy and safety of intensity modulated radiotherapy combined with 5-fluorouracil(5-FU)+oxaliplatin in patients with locally advanced nasopharyngeal carcinoma.Methods A total of 66 patients with locally advanced nasopharyngeal carcinoma who were treated in our hospital from January 2019 to December 2020 were selected as the research subjects,and they were divided into the control group and the observation group accoding to the single and even number of admission,with 33 cases in each group.Both groups received radical concurrent intensity modulated radiotherapy and 5-FU intravenous drip treatment,the control group was combined with cisplatin intravenous drip on the basis of the above treatment,and the observation group was combined with oxaliplatin intravenous drip treatment.The short-term efficacy,6-month survival rate,recurrence rate,distant tumor metastasis rate and occurrence of adverse reactions were compared between the two groups.Results There was no significant difference in the total effective rate between the two groups.There was no significant difference in 6-month survival rate,recurrence rate and distant metastasis rate between the two groups.The incidence of adverse reactions in the observation group was 21.21%,which was lower than 45.45%in the control group,and the difference was statistically significant(P<0.05).Conclusion The efficacy of 5-FU,oxaliplatin combined with 5-FU+cisplatin in the treatment of patients with locally advanced nasopharyngeal carcinoma during intensity modulated radiotherapy is comparable to that of 5-FU,cisplatin chemotherapy,and the drug toxicity of oxaliplatin adjuvant chemotherapy is weak.

关 键 词：调强放疗 5-氟尿嘧啶 奥沙利铂 顺铂 局部晚期鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]