结直肠癌患者实施腹腔镜微创根治术的临床疗效  

Clinical Efficacy of Laparoscopic Minimally Invasive Radical Surgery for Colorectal Cancer Patients

作　　者：于晨[1] YU Chen(Weifang People's Hospital,Weifang 261041,China)

机构地区：[1]潍坊市人民医院,山东潍坊261041

出　　处：《中国医药指南》2023年第33期68-71,共4页Guide of China Medicine

摘　　要：目的对腹腔镜微创根治术在结直肠癌治疗中的临床运用效果进行探析。方法选择结直肠癌82例为研究对象,均于2020年1月至2022年12月在我院接受治疗,按随机数字表法分成两组,对照组采取常规开腹手术,研究组采取腹腔镜微创根治术。对比两组治疗结果。结果研究组各项手术指标与对照组相对比明显更低(P<0.05)。两组胃肠功能恢复时间如肛门排气、肠鸣音恢复、恢复进食等相比较,研究组均低于对照组患者(P<0.05)。两组治疗前IL-6、IL-8、CRP、TNF-α等指标相比较,无明显差异(P>0.05);治疗后均有所上升,与本组治疗前对比,差异明显,同时研究组治疗后IL-6、IL-8、CRP、TNF-α等指标低于对照组治疗后(P<0.05)。两组治疗前相关炎性指标值无差异(P>0.05);治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)指标均有所下降,而CD8^(+)指标则有所提高,但研究组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)指标高于对照组治疗后,且CD8^(+)指标低于对照组治疗后(P<0.05)。研究组并发症发生率为4.88%比对照组患者19.51%低,差异明显(χ^(2)=4.100,P<0.05)。结论对结直肠癌患者予以腹腔镜微创根治术治疗,疗效甚佳,能改善患者的胃肠功能,降低炎性因子水平,改善免疫功能。Objective To explore the clinical application effect of laparoscopic minimally invasive radical surgery in the treatment of colorectal cancer.Methods A total of 82 cases of colorectal cancer were selected and treated in our hospital from January 2020 to December 2022.They were randomly divided into two groups according to the number table method.The control group received routine open surgery,while the study group received laparoscopic minimally invasive radical surgery.Compare the treatment results between the two groups.Results The surgical indicators in the study group were significantly lower than those in the control group(P<0.05).Compared with the two groups,the recovery time of gastrointestinal function,such as anal exhaust,bowel sound recovery,and resumption of eating,was lower in the study group than in the control group(P<0.05).Two groups of IL-6,IL-8,CRP,TNF-αbefore treatment Compared with other indicators,there was no significant difference(P>0.05).After treatment,the levels of IL-6,IL-8,CRP,and TNF-αin the study group increased significantly compared to before treatment the indicators were lower than those in the control group after treatment(P<0.05).There was no difference in the values of relevant inflammatory indicators between the two groups before treatment(P>0.05);After treatment,the CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)indicators all decreased,while the CD8^(+)indicators increased.However,the CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)indicators in the study group were higher than those in the control group after treatment,and the CD8^(+)indicators were lower than those in the control group after treatment(P<0.05);The incidence of complications in the study group was 4.88%,which was significantly lower than 19.51%in the control group(χ^(2)=4.100,P<0.05).Conclusions Laparoscopic minimally invasive radical surgery for colorectal cancer patients has a good therapeutic effect,which can improve gastrointestinal function,reduce inflammatory factor levels,and improve immune function.

关 键 词：结直肠癌 腹腔镜微创根治术 开腹手术 

分 类 号：R735[医药卫生—肿瘤]