胃癌、胃癌前状态及病变黏膜组织MUC及EGFR的表达与Hp感染的关系  

The relationship of expression of MUC and EGFR in gastric cancer,gastric precancerous state and mucosal lesions with Hp infection

作　　者：谷培 常丽丽 牛晓蕾 张海玲 王俊丽 刘红芬 GU Pei;CHANG Li-li;NIU Xiao-lei;ZHANG Hai-ling;WANG Jun-li;LIU Hong-fen(The First Department of Gastroenterology,Shijiazhuang People′s Hospital,Hebei Province,Shijiazhuang 050000,China;The Fifth Department of Gastroenterology,Shijiazhuang People′s Hospital,Hebei Province,Shijiazhuang 050000,China;The Second Department of Gastroenterology,Shijiazhuang People′s Hospital,Hebei Province,Shijiazhuang 050000,China)

机构地区：[1]河北省石家庄市人民医院消化一科,河北石家庄050000 [2]河北省石家庄市人民医院消化五科,河北石家庄050000 [3]河北省石家庄市人民医院消化二科,河北石家庄050000

出　　处：《河北医科大学学报》2023年第11期1255-1259,共5页Journal of Hebei Medical University

基　　金：河北省医学科学研究课题计划(20210923)。

摘　　要：目的探讨胃癌、胃癌前状态及病变黏膜组织黏蛋白(mucoprotein,MUC)2、6及表皮生长因子受体(epidermal growth factor receptor,EGFR)的表达与幽门螺旋杆菌(Helicobacter pylori,Hp)感染的关系。方法选择胃腺癌患者50例;癌前状态及病变患者50例,病理检查提示有腺体萎缩或异型增生、肠化生。另选胃镜示慢性非萎缩性胃炎患者50例作为对照组,病理提示无腺体萎缩、异型增生及肠化生。采用免疫组织化学法检测各组的EGFR、MUC2、MUC6表达,快速尿素酶试验和组织学改良Giemsa染色检测Hp。结果与对照组相比,胃癌组、癌前状态及病变组的MUC2、Hp、EGFR阳性率高,MUC6阳性率低,差异有统计学意义(P<0.05)。与癌前状态及病变组相比,胃癌组MUC2、Hp、EGFR阳性率高,MUC6阳性率低,差异有统计学意义(P<0.05)。Hp阳性感染胃癌组与癌前状态及病变组的MUC2、EGFR阳性率均高于Hp阴性组,MUC6阳性率低于HP阴性组,差异有统计学意义(P<0.05)。MUC2和EGFR的阳性表达率与Hp感染呈现正相关关系,MUC6的阳性表达率与Hp感染呈现负相关关系(P<0.05)。结论Hp感染后会上调MUC2、EGFR在体内的表达,下调MUC6的表达,在胃癌发展中具有非常重要的作用,通过检测Hp及MUC2、MUC6、EGFR表达可以识别胃癌高危人群。Objective To investigate the relationship between the expression of mucoprotein2(MUC2),mucoprotein6(MUC6)and epidermal growth factor receptor(EGFR)in gastric cancer,precancerous state and mucosal lesions with Helicobacter pylori(Hp)infection.Methods Fifty patients with gastric adenocarcinoma and 50 patients with precancerous state and lesions were selected.Pathological examination showed atrophy of glands,dysplasia or intestinal metaplasia.In addition,50 patients with chronic non-atrophic gastritis under gastroscope were selected as the control group.Pathology showed no gland atrophy,dysplasia,or intestinal metaplasia.EGFR,MUC2 and MUC6 expression levels were detected by immunohistochemistry,and rapid urease test and histologically modified Giemsa staining were used to detect Hp.The relationship between the expression of EGFR,MUC2,MUC6 and Hp infection was analyzed.Results Compared with the control group,the positive rates of MUC2,Hp,and EGFR in the gastric cancer group and precancerous state and lesion group were higher,while the positive rates of MUC6 were lower,with statistically significant differences(P<0.05).Compared with the precancerous state and lesion group,the gastric cancer group had a higher positive rate of MUC2,Hp,and EGFR,and a lower positive rate of MUC6,with a statistically significant difference(P<0.05).The positive rates of MUC2 and EGFR in the Hp positive gastric cancer group and precancerous state and lesion group were higher than those in the Hp negative group,while the positive rates of MUC6 were lower than those in the HP negative group,with statistical significance(P<0.05).The positive expression rates of MUC2 and EGFR were positively correlated with Hp infection,while the positive expression rates of MUC6 were negatively correlated with Hp infection(P<0.05).Conclusion Hp infection can increase the expression of MUC2 and EGFR in vivo and decrease the expression of MUC6,which plays a very important role in the development of gastric cancer.Detecting Hp and the expression of MUC2,MUC6,EGFR

关 键 词：胃肿瘤 胃黏蛋白类 幽门螺旋杆菌感染 

分 类 号：R735.2[医药卫生—肿瘤]