基于自适应光学的视网膜成像技术应用进展  

Advancements in the application of adaptive optics-based retinal imaging technology

作　　者：张影 张荟颖 姚进 Ying Zhang;Hui-Ying Zhang;Jin Yao(The Affiliated Eye Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China)

机构地区：[1]南京医科大学眼科医院,江苏省南京市210029

出　　处：《国际眼科杂志》2023年第12期1978-1982,共5页International Eye Science

基　　金：国家自然科学基金面上项目(No.82271107)。

摘　　要：自适应光学(AO)是一种通过减少波前畸变来降低光学像差影响,从而改进光学系统性能的技术。基于AO的视网膜成像技术减少了屈光系统光学像差的产生,从而提高了视网膜成像的分辨率和质量,这种活体视网膜细胞水平的成像技术,具有巨大的眼科应用潜力。AO与眼底相机、扫描激光检眼镜、光学相干断层扫描技术及光学相干断层血管造影结合,可以应用于健康人群眼底视锥细胞分布情况、形态特征和功能作用观察,并在更精细的血管层面了解视网膜血管形态和灌注情况;可以对病变眼底中细胞数量和形态、筛板以及视网膜微血管系统和神经组织等微观结构进行定性和定量分析,从而作为糖尿病视网膜病变、年龄相关性黄斑变性、青光眼、遗传性视网膜疾病等眼病早期诊断、进展检测和治疗效果随访观察的新手段。Adaptive optics(AO)is a technique used to optimize the functionality of optical systems through the reduction of wavefront distortion and optical aberrations.AO-based retinal imaging reduces the occurrence of optical aberrations in the refractive system,consequently improving the resolution and overall quality of retinal imaging.As a result,AO-based retinal imaging has potential wide-ranging application in ophthalmology.A combination of AO,fundus camera,scanning laser ophthalmoscope,optical coherence tomography technique and optical coherence tomography angiography,can be applied to observe the distribution,morphology and function of retinal cone cells in the healthy retinal,and to comprehend the shape and perfusion of retinal vessels in the fine vascular layer.With this technique,it can also possible to perform qualitative and quantitative analysis of the number and shape of cells in the ocular fundus,the cribriform plate,and the microscopic structures of the retinal microvascular system and nerve tissue.It can be expected as a novel tool for the early diagnosis,follow-up of therapy effects,and identification of progression of ophthalmic diseases such as diabetic retinopathy,age-related macular degeneration,glaucoma and hereditary retinal diseases.

关 键 词：自适应光学 视网膜成像 眼底检查 眼部疾病 

分 类 号：R774.1[医药卫生—眼科]