巩膜胶原交联防治病理性近视有效性及安全性的研究进展  

Advances in the efficacy and safety of scleral collagen cross-linking in the prevention and treatment of pathologic myopia

作　　者：吕文超 梁甜 王丽娜 闫春妮[1] 晁媛媛 宋金鑫[1] Wen-Chao Lyu;Tian Liang;Li-Na Wang;Chun-Ni Yan;Yuan-Yuan Chao;Jin-Xin Song(Xi'an No.1 Hospital,Shaanxi Institute of Ophthalmology,Xi'an 710002,Shaanxi Province,China)

机构地区：[1]中国陕西省西安市第一医院、陕西省眼科研究所,710002

出　　处：《国际眼科杂志》2023年第12期2021-2025,共5页International Eye Science

基　　金：陕西省重点研发计划项目(No.2023-YBSF-637);西安市科技计划项目(No.2022YXYJ0079)。

摘　　要：2004年Wollensak和Spoerl首次将物理交联和化学交联方法应用到巩膜组织中,发现核黄素/紫外线A、甘油醛和戊二醛交联巩膜可以提高巩膜的生物力学性能,提出巩膜胶原交联有望成为一种治疗病理性近视的新方法。近年来从多物种多方法近视动物模型的建立、交联方法的改良、巩膜组织生物力学性能测量方法的改进、增加对在体生物参数如视网膜神经纤维层厚度、视网膜电图波幅等的测量等多方面对物理交联和化学交联巩膜防治病理性近视的有效性和不良反应进行了一系列新的探索。京尼平交联巩膜胶原联合后巩膜收缩或加固术已经应用至临床研究,本文就巩膜胶原物理交联和京尼平化学交联方法做一综述来探讨该方法防治病理性近视的有效性及安全性。In 2004,it was the first time that Wollensak and Spoerl had applied physical and chemical cross-linking methods to scleral tissue.They found that the biomechanical strength of cross-linked sclera,induced by riboflavin/ultraviolet A,glyceraldehyde and glutaraldehyde,could be improved and proposed that scleral collagen cross-linking is expected to be a new method for the treatment of pathologic myopia.In recent years,a series of explorations have been made on the effectiveness and adverse reactions of physical and chemical cross-linking in the prevention and treatment of pathologic myopia,including the establishment of various animal models and different myopia modeling methods,the improvement of cross-linking methods,the amelioration of the measurement of biomechanical strength of scleral tissue and the attention of biological parameters such as the thickness of retinal nerve fiber layer and the amplitude of electroretinogram in vivo.Genipin-crosslinking of the scleral collagen combined with posterior scleral contraction/reinforcement has been applied to clinical research.This review summarizes physical cross-linking and the genipin-crosslinking of scleral collagen to explore the effectiveness and safety of the methods in the prevention and treatment of the pathologic myopia.

关 键 词：病理性近视 巩膜 交联 京尼平 后巩膜加固 

分 类 号：R778.11[医药卫生—眼科]