内皮细胞诱导脑动静脉畸形发生发展作用机制的研究进展  

Advances in the mechanism of endothelium-induced development of cerebral arteriovenous malformations

作　　者：庞淼 尚成浩 张雨杭 张广浩 李喆 段国礼 许奕 刘建民 李强 Pang Miao;Shang Chenghao;Zhang Yuhang;Zhang Guanghao;Li Zhe;Duan Guoli;Xu Yi;Liu Jianmin;Li Qiang(Cerebrovascular Disease Center,the First Affiliated Hospital of Naval Military Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院脑血管病中心,上海200433

出　　处：《中国脑血管病杂志》2023年第11期777-782,共6页Chinese Journal of Cerebrovascular Diseases

基　　金：海军军医大学第一附属医院“234学科攀峰计划”(2020YXK033)。

摘　　要：脑动静脉畸形(bAVM)是青年颅内出血的重要原因。大量研究结果表明,内皮细胞是bAVM异常血管结构形成过程中的关键细胞。该文通过回顾相关文献,对内皮细胞在bAVM发生、发展过程中的作用机制,以及血流动力学、炎性反应等血管微环境调控内皮细胞促进bAVM生长、破裂的相关机制进行了综述,并对bAVM的形成机制与潜在治疗方案进行了总结与展望。Brain arteriovenous malformations(bAVM)is an important cause of intracranial hemorrhage in adolescents.A large number of studies have shown that endothelial cells are the key cells in the formation of abnormal vascular structure in bAVM.This paper reviewd the mechanism of endothelial cells in the occurrence and development of bAVM and the mechanism of endothelial cells in promoting the growth and rupture of bAVM regulated by vascular microenvironments such as hemodynamics and inflammation.The formation mechanism and potential treatment of bAVM were summarized and prospected.

关 键 词：颅内动静脉畸形 内皮细胞 血管微环境 综述 

分 类 号：R743[医药卫生—神经病学与精神病学]