红细胞内ATP释放的机制、效应及其与疾病关系的研究进展  

Progress in mechanism and effect of ATP release from erythrocytes and its relationship with diseases

作　　者：梁浩 王玉路[1] 王云霞[2] 刘治 苏燕[3] LIANG Hao;WANG Yulu;WANG Yunxia;LIU Zhi;SU Yan(Department of Traumatology,The First Affiliated Hospital of Baotou Medical College,Baotou 014010,China;Baotou Central Hospital,Baotou 014040,China;Department of Biochemistry and Molecular Biology,Baotou Medical College,Baotou 014040,China)

机构地区：[1]包头医学院第一附属医院创伤一科,内蒙古包头014010 [2]包头市中心医院,内蒙古包头014040 [3]包头医学院基础医学院生物化学与分子生物学教研室,内蒙古包头014040

出　　处：《中国病理生理杂志》2023年第11期2089-2094,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81860029);内蒙古自治区自然科学基金项目(No.2020MS08008)。

摘　　要：成熟红细胞(erythrocyte)由于无细胞核及含膜细胞器,主要通过糖酵解和磷酸戊糖途径进行能量代谢。糖酵解产生的三磷酸腺苷(adenosine triphos-phate,ATP)作为红细胞内主要能源物质,以往认为主要用于维持红细胞正常功能。早在1997年Mc-Cullough等就观察到缺氧或红细胞变形时,ATP可以被红细胞释放到细胞外。Erythrocytes do not possess mitochondria and mainly rely on glycolysis to synthesize adenosine triphosphate(ATP).The ATP generated within cells can support normal cellular activity and be released through the pannexin 1 channel in the cell membrane.Extracellular ATP participates in the synthesis and release of nitric oxide in vascular endothelial cells,platelet activation and aggregation,and the regulation of red blood cell physiological activities under hypoxic conditions.Moreover,it may promote self-inflammatory reactions under specific conditions.Therefore,the release of ATP from red blood cells is related to the occurrence and development of sickle cell disease,diabetes,aging,and other diseases.To provide a reference for future research on red blood cell energy metabolism,this article reviews the processes of ATP synthesis and release in red blood cells,the physiological effects after ATP release,and the relationship between ATP and various diseases.

关 键 词：红细胞 ATP释放 疾病 

分 类 号：R363.2[医药卫生—病理学] R329.25[医药卫生—基础医学]