外泌体微小RNA-130a在肿瘤中的研究进展  

Research progress of exosomes derived microRNA-130a in progression of cancer

作　　者：周涛[1] 蒙国鑫 张伟[1] Zhou Tao;Meng Guoxin;Zhang Wei(Department of Cardiac Surgery,Guizhou Provincial People’s Hospital,Guiyang 550002,China)

机构地区：[1]贵州省人民医院心外科,贵阳550002

出　　处：《中华实验外科杂志》2023年第10期2111-2115,共5页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81960050,82160056);贵州省科技计划项目(科学技术基金)(黔科合基础[2020]1Y293号);贵州省卫生健康委员会科学技术基金项目(gzwkj 2021-193);贵州省人民医院国家自然科学基金后补助基金(GPPH-NSFC-2019-24,GPPH-NSFC-2021-16)。

摘　　要：外泌体携带的微小RNA在肿瘤发生、基因表达、生物途径、基因沉默和耐药性中发挥重要作用,已被认为是肿瘤转移的关键调节因子,是潜在的诊断生物标志物。miR-130a参与各种生理过程以及细胞凋亡、肿瘤进展、炎性反应等病理进程。现综述外泌体miR-130a对肿瘤进展的影响和调控机制。MicroRNAs carried by extracellular vesicles play a role in the occurrence,gene expression,biological pathways,gene silencing,and drug resistance of cancers,and have been recognized as key regulatory factors for tumor metastasis and potential diagnostic biomarkers.MiR-130a is involved in various physiological processes and pathological processes such as cell apoptosis,tumor progression,and inflammatory response.This article reviews the impact and regulatory mechanism of miR-130a on the progression of cancers.

关 键 词：肿瘤 调控机制 外泌体 微小RNA-130a 

分 类 号：R730.2[医药卫生—肿瘤]