乙醛脱氢酶2在缺血再灌注损伤中的研究进展  

Research progress of aldehyde dehydrogenase 2 in ischemia reperfusion injury

作　　者：卡丽毕努尔·亚森 叶啟发[1,2] 钟自彪[1] Kalibinuer·Yasen;Ye Qifa;Zhong Zibiao(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,China;The 3rd Xiangya Hospital of Central South University,Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Changsha 410013,China)

机构地区：[1]武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植医学中心,移植医学技术湖北省重点实验室,武汉430071 [2]中南大学湘雅三医院,卫生部移植医学工程技术研究中心,长沙410013

出　　处：《中华实验外科杂志》2023年第10期2134-2138,共5页Chinese Journal of Experimental Surgery

基　　金：湖北省重点研发计划(2021BCA122)。

摘　　要：缺血再灌注损伤(IRI)是指血供中断再通后,组织器官损伤加重的过程,其损伤机制复杂,主要包括氧化应激、钙超载、炎性反应等,由此引起的临床疾病称为再灌注综合征。乙醛脱氢酶2(ALDH2)是人体乙醇代谢过程中的关键酶,主要功能是将乙醛代谢成无毒的乙酸。近年来有大量研究表明,ALDH2在缺血再灌注损伤中有明确的保护性作用,其特异性激动剂Alda-1也被广泛运用于IRI相关研究中。本文就ALDH2的结构、功能、基因多态性和在各器官IRI中的研究进展进行了综述,探讨ALDH2成为IRI治疗靶点的可能性。Ischemia reperfusion injury(IRI)refers to the process of tissue and organ damage aggravated after blood supply is interrupted and rerouted.The injury mechanism is complex,including oxidative stress,calcium overload,inflammatory response,etc.,and the clinical diseases caused by IRI are called reperfusion syndrome.Acetaldehyde dehydrogenase 2(ALDH2)is a key enzyme in the process of ethanol metabolism,and its main function is to metabolize acetaldehyde into non-toxic acetic acid.In recent years,a large number of studies have shown that ALDH2 has a clear protective effect on ischemia-reperfusion injury,and its specific agonist Alda-1 has also been widely used in IRI related studies.In this paper,the structure,function,gene polymorphism of ALDH2 and the research progress in IRI were reviewed,and the possibility of ALDH2 as a therapeutic target of IRI was discussed.

关 键 词：乙醛脱氢酶2 缺血再灌注损伤 Alda-1 

分 类 号：R575[医药卫生—消化系统]