房水中炎性因子及MMP-2在高度近视中的作用  

The role of inflammatory factors and MMP-2 in aqueous humor in high myopia

作　　者：李廷军[1] 邱婷婷[1] LI Ting-jun;QIU Ting-ting(Laboratory Department,Ji'nan Second People's Hospital,Ji'nan Shandong Province 250001,China)

机构地区：[1]济南市第二人民医院检验科,山东济南250001

出　　处：《中国城乡企业卫生》2023年第10期136-138,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的 分析房水中炎性因子、基质金属蛋白酶2(MMP-2)的表达在高度近视患者致病中的作用及其与眼轴长度的关系。方法 选择济南市第二人民医院收治的行巩膜加固手术治疗的高度近视患者30例作为观察组,另选择行白内障超声乳化术治疗患者30例为对照组;采集受试者房水样品并检测其中IL-6、IL-1β、TGF-β及MMP-2水平。分析炎性因子及MMP-2水平与眼轴相关性,并探究高度近视患者致病的危险因素。结果 观察组患者眼轴长度为(29.84±1.43)mm,长于对照组患者的(23.12±1.08)mm,差异有统计学意义(t=20.539,P<0.01)。观察组患者房水中IL-6、IL-1β、TGF-β及MMP-2水平均明显高于对照组,差异均有统计学意义(P<0.01)。高度近视患者患眼房水中IL-6、IL-1β、TGF-β及MMP-2水平与眼轴长度呈现明显的正相关关系;房水中IL-6、IL-1β、TGF-β及MMP-2升高是导致患者出现高度近视的独立性危险因素。结论 房水中炎性因子、MMP-2的高表达是导致高度近视患者发病的主要危险因素,且其与眼轴长度呈明显正相关。Objective To analyze the role of inflammatory factors and MMP-2 expression in aqueous humor in the pathogenesis of high myopia and their relationship with eye axial length.Methods A total of 30 patients with high myopia who underwent scleral reinforcement surgery admitted to Ji'nan Second People's Hospital were selected as the observation group,and 30 patients who underwent cataract phacoemulsification surgery were selected as the control group;the aqueous humor samples from subjects were collected to detect IL-6,IL-1β,TGF-βand MMP-2 levels.The correlation between inflammatory factors and MMP-2 levels with ocular axis were aralyzed to explore the risk factors for high myopia in patients.Results The eye axial length of the observation group was(29.84±1.43)mm,which was significantly longer than that of the control group with(23.12±1.08)mm,and the difference was statistically significant(t=20.539,P<0.01).The levels of IL-6,IL-1β,TGF-βand MMP-2 in aqueous humor of patients in the observation group were significantly higher than those of the control group,and the differences were statistically significant(P<0.01).There was a significant positive correlation between the levels of IL-6,IL-1β,TGF-β and MMP-2 with axial length of the eye in patients with aqueous homor;theelevated levels of IL -6,IL -1β,TGF -β and MMP-2 were independent risk factors for high myopia inpatients. Conclusion The high expression of inflammatory factors and MMP-2 in aqueous humor was themain risk factor for the onset of high myopia in patients,and it was also significantly positively correlatedwith eye axial length.

关 键 词：房水 炎性因子 基质金属蛋白酶2 高度近视 眼轴长度 

分 类 号：R778.11[医药卫生—眼科]