5-氨基酮戊酸光动力疗法治疗口腔潜在恶性疾患中药物因素影响的分析  

Analysis of drug factors in 5-aminolevulinic acid photodynamic therapy for oral potentially malignant disorder

作　　者：李丹丹 于竹君 聂成 王建莉[1] Li Dandan;Yu Zhujun;Nie Cheng;Wang Jianli(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Dept.of Pharmacy,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院药剂科,成都610041

出　　处：《华西口腔医学杂志》2023年第6期701-707,共7页West China Journal of Stomatology

基　　金：四川大学华西口腔医院探索与研发项目(RD-01-202309)。

摘　　要：目的探讨药物因素对5-氨基酮戊酸(ALA)光动力疗法治疗口腔潜在恶性疾患疗效的影响,以期提高临床疗效及推动临床合理用药。方法检索Pubmed、ISI Web of Knowledge数据库、中国知网、维普以及万方数据库中关于ALA光动力疗法治疗口腔潜在恶性疾患的临床研究,并进行文献分析。结果检索到ALA光动力疗法治疗口腔潜在恶性疾患的临床研究病例共690例,平均完全缓解率为65.94%;16.8%氨基酮戊酸甲酯乳膏组、局部外用组、每周1次组及预激活时间2~4 h组优于其他亚组,平均完全缓解率分别为100%、66.91%、78.28%及77.54%。结论药物因素对5-氨基酮戊酸光动力疗法治疗口腔潜在恶性疾患疗效有直接影响,从药物改良的角度开发新的口腔ALA制剂是提高疗效的重要途径。Objective This study aimed to analyze the influence of drug factors on the efficacy of 5-aminolevulinic acid(ALA)photodynamic therapy for oral potentially malignant disorder to improve clinical efficacy and promote clinical rational drug use.Methods Literature on the treatment of oral potentially malignant disorder by using ALA photodynamic therapy was collected and analyzed from PubMed,ISI Web of Knowledge database,CNKI,VIP,and Wanfang database.Results A total of 690 cases were collected,with an average complete response rate of 65.94%.The groups treated with 16.8%methyl aminolevulinate cream,local topical,once a week,and pre-activation time of 2−4 hours were better than the other subgroups,with average complete response rates of 100%,66.91%,78.28%,and 77.54%,respectively.Conclusion Drug factors have direct influence on the curative effect.The development of novel oral ALA formulations from the perspective of drug improvement is an important strategy to improve efficacy.

关 键 词：5-氨基酮戊酸 光动力疗法 药物因素 口腔潜在恶性疾患 新制剂 

分 类 号：R781.5[医药卫生—口腔医学]