丙戊酸钠联合左乙拉西坦治疗儿童癫痫的临床效果及其神经保护作用分析  

Clinical Effect of Sodium Valproate Combined with Levetiracetam in the Treatment of Epilepsy in Children and Analysis of Its Neuroprotective Effect

作　　者：董秋峰 闫志丰[2] 杨鑫 李鹏起 甄海宁 Dong Qiufeng;Yan Zhifeng;Yang Xin;Li Pengqi;Zhen Haining(Department of Neurosurgery,Xijing Hospital of Air Force Medical University,Xian 710032,Shanxi Province,China;Department of Neurosurgery,the First Affiliated Hospital of Xian Medical College,Xian 710077,Shanxi Province,China;Department of Neurosurgery,the Third Affiliated Hospital of Xian Medical College,Xian 710068,Shanxi Province,China;Department of Neurosurgery,PLA 957th Hospital,Ali 859000,Xizang Autonomous Region,China)

机构地区：[1]空军军医大学附属西京医院神经外科,陕西西安710032 [2]西安医学院第一附属医院神经外科,陕西西安710077 [3]西安医学院第三附属医院神经外科,陕西西安710068 [4]解放军第957医院神经外科,西藏自治区阿里859000

出　　处：《中外医药研究》2023年第21期39-41,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：陕西省社会发展攻关计划项目(编号:2014K11-01-02-07);空军军医大学西京医院学科助推计划创新人才项目(编号:XJZT08R09)。

摘　　要：目的:评估丙戊酸钠联合左乙拉西坦治疗儿童癫痫的临床效果及其神经保护作用。方法:选取2022年1—6月空军军医大学西京医院收治的癫痫患儿80例为研究对象,随机分为对照组与试验组,各40例。对照组接受丙戊酸钠片治疗,试验组在对照组基础上给予左乙拉西坦治疗。比较两组临床疗效、血清神经元特异性烯醇化酶(NSE)、不良反应发生率。结果:试验组总有效率高于对照组,差异有统计学意义(P=0.011);治疗后,试验组NSE水平低于对照组,差异有统计学意义(P<0.001);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丙戊酸钠联合左乙拉西坦治疗儿童癫痫的效果显著,能有效控制癫痫发作,对神经元有良好的保护作用,同时其用药安全可靠,值得推广。Objective:To evaluate the clinical effect of sodium valproate combined with levetiracetam in the treatment of epilepsy in children and its neuroprotective effect.Methods:Eighty cases of children with epilepsy admitted to Xijing Hospital of Air Force Medical University from January to June 2022 were selected for the study,and were randomly divided into the control group and the experimental group,each with forty cases.The control group was treated with sodium valproate tablets,and the experimental group was treated with levetiracetam on the basis of the control group.The clinical efficacy,serum neuron-specific enolase(NSE),and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P=0.011);After treatment,the NSE level of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.001);Comparison of the incidence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion:Sodium valproate combined with levetiracetam in the treatment of epilepsy in children is effective in controlling epileptic seizures and has a good protective effect on neurons,and at the same time,its medication is safe and reliable,and it is worth promoting.

关 键 词：左乙拉西坦 儿童 癫痫 神经保护 

分 类 号：R74[医药卫生—神经病学与精神病学]