Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models  

作　　者：Sanika M.Joshi Theresa Currier Thomas Nafisa M.Jadavji 

机构地区：[1]College of Osteopathic Medicine,Midwestern University,Glendale,CA,USA [2]Department of Biomedical Sciences,Midwestern University,Glendale,CA,USA [3]Department of Child Health,College of Medicine–Phoenix,University of Arizona,Phoenix,AZ,USA [4]College of Veterinary Medicine,Midwestern University,Glendale,CA,USA [5]Department of Neuroscience,Carleton University,Ottawa,Canada

出　　处：《Neural Regeneration Research》2024年第8期1728-1733,共6页中国神经再生研究(英文版)

基　　金：Salary for TCT was supported by National Institutes of Health Grant(R01NS100793)。

摘　　要：Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals yearly.One-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic stroke.However,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more investigation.The aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain injury.PubMed,Web of Science,and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury outcomes.The search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and B-vitamins.The focus of each literature search was basic science data.The year of publication in the literature searches was not limited.Our analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to controls.Howeve r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain injury.The details of supplementation post-traumatic brain injury need to be further investigated.Overall,we conclude that B-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model systems.Further investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关 键 词：folic acid NICOTINAMIDE one-carbon metabolism RIBOFLAVIN traumatic brain injury vitamin B12 vitamin B2 vitamin B3 

分 类 号：R651.15[医药卫生—外科学]