NICOTINAMIDE

作品数：89被引量：214H指数：8
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相关机构：暨南大学中山大学附属第二医院广东医科大学三峡大学人民医院更多>>
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Nicotinamide N-methyltransferase negatively regulates metastasis-promoting property of cancer-associated fibroblasts in lung adenocarcinoma
《Cancer Communications》2025年第2期110-137,共28页Peiyu Wang Guangxi Wang Haoran Li Yuyao Yuan Haiming Chen Shaodong Wang Zewen Sun Fanjie Meng Yun Li Fan Yang Jun Wang Kezhong Chen Mantang Qiu 
National Natural Science Foundation of China,Grant/Award Numbers:92059203,82173386;National Key R&D Program of China,Grant/Award Number:2023YFF0723500;Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer,Chinese Academy of Medical Sciences,Grant/Award Number:2021RU002;Medical and Health Science and Technology Innovation project,Grant/Award Number:2021-I2M-002;Beijing Nova Program,Grant/Award Number:20230484314;Innovation Fund for Excellent PhD student of Peking University Health Science Center,Grant/Award Number:2022-58。
Background:Recurrence and metastasis remain significant challenges in lung adenocarcinoma(LUAD)after radical resection.The mechanisms behind the recurrence and metastasis of LUAD remain elusive,and deregulated cellula...
关键词：Nicotinamide N-methyl transferase Lung cancer Cancer-associated fibroblast Extracellular matrix Metastasis 
Cardiovascular and nonalcoholic fatty liver disease:Sharing common ground through SIRT1 pathways
《World Journal of Cardiology》2024年第11期632-643,共12页Kenneth Maiese 
Supported by American Diabetes Association;American Heart Association;NIH NIEHS;NIH NIA;NIH NINDS;NS053956;NIH ARRA.
As a non-communicable disease,cardiovascular disorders have become the lea-ding cause of death for men and women.Of additional concern is that cardio-vascular disease is linked to chronic comorbidity disorders that in...
关键词：AMP-activated protein kinase Cardiovascular disease Diabetes mellitus ERYTHROPOIETIN Metabolic-dysfunction-associated steatotic liver disease NICOTINAMIDE Nicotinamide adenine dinucleotide Nonalcoholic fatty liver disease Silent mating type information regulation 2 homolog 1(Saccharomyces cerevisiae) Stem cells 
Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models
《Neural Regeneration Research》2024年第8期1728-1733,共6页Sanika M.Joshi Theresa Currier Thomas Nafisa M.Jadavji 
Salary for TCT was supported by National Institutes of Health Grant(R01NS100793)。
Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals yearly.One-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemi...
关键词：folic acid NICOTINAMIDE one-carbon metabolism RIBOFLAVIN traumatic brain injury vitamin B12 vitamin B2 vitamin B3 
Double-stranded DNA-nucleic acid dye complex-sensitized biocatalytic photosynthesis:Base pairing-switched regeneration of nicotinamide cofactor
《Journal of Energy Chemistry》2024年第7期618-624,共7页Zhen Dong Yanying Wang Dan Li Peng Wu 
the financial support from the National Natural Science Foundation of China (22274102 and 22325403);the Fundamental Research Funds from Sichuan University (2022SCUNL104);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(2022A02)
Photo-biocatalysis,the combination of photosensitization and biocatalysis,is an emerging solution for sunlight-based renewable energy.It is thus important to develop light antennas with both good light har-vesting and...
关键词：PHOTOSYNTHESIS DSDNA SYBRGreenI TICT 2-phenylpropanol 
Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro
《World Journal of Stem Cells》2024年第2期163-175,共13页Yan Ren Yan-Ni Cui Hong-Wei Wang 
the Science and Technology Department of Shanxi Province,No.YDZJSX2021B009;Health Commission of Shanxi Province,No.2021XM07;Shanxi Provincial Department of Education,No.2023KY380.
BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital resource.Nicotinamide(NAM)can promote HSC expansion ex vivo,but its effect...
关键词：Hematopoietic stem cells NICOTINAMIDE Concentration PROLIFERATION DIFFERENTIATION Sirtuin 1 
Characterization of long-term ex vivo expansion of tree shrew spermatogonial stem cells被引量：3
《Zoological Research》2023年第6期1080-1094,共15页Cong Li Rui Bi Lin Wang Yu-Hua Ma Yong-Gang Yao Ping Zheng 
supported by the Ministry of Science and Technology of China (2021YFF0702700,STI2030-Major Project2021ZD0200900);National Natural Science Foundation of China (U2102202,U1702284);Yunnan Province (202305AH340006)。
Tree shrews(Tupaia belangeri chinensis)share a close relationship to primates and have been widely used in biomedical research.We previously established a spermatogonial stem cell(SSC)-based gene editing platform to g...
关键词：Tree shrews Spermatogonial stem cells Nicotinamide riboside DNA damage Mitochondrial dysfunction 
Nicotinamide N-methyltransferase and liver diseases
《Genes & Diseases》2023年第5期1883-1893,共11页Guangyu Liang Ying Li Yan Lin Xiao Yang Jiankun Yang Shaobo Hu Anding Liu 
supported by grants from the National Natural Science Fund of China(NSFC)(No.82071590).
Cellular metabolism-induced epigenetic regulation is essential for the maintenance of cellular homeostasis.Nicotinamide N-methyltransferase(NNMT)is emerging as a key point of intersection between cellular metabolism a...
关键词：EPIGENETICS Liver diseases METABOLISM Nicotinamide N-methyltransferase Non-alcoholic fatty liver disease 
Plasma metabolic profiling reveals that chromium yeast alleviates the negative effects of heat stress in mid-lactation dairy cows被引量：1
《Animal Nutrition》2023年第2期401-410,共10页Yeqianli Wo Fengtao Ma Qiang Shan Duo Gao Yuhang Jin Peng Sun 
supported by the National Key Research and Development Program of China(2022YFD1300505,2022YFD1301101);the earmarked fund for China Agriculture Research System(CARS-37);the Agricultural Science and Technology Innovation Program(cxgc-ias-07).
Chromium yeast(CY)supplementation has the potential to alleviate the negative effects of heat stress in dairy cows,but the mechanism remains elusive.We aimed to identify the metabolic mechanisms whereby CY supplementa...
关键词：Chromium yeast Heat stress Metabolomics NICOTINAMIDE Dairy cow 
Discovery of tetrazolium nicotinamide derivatives as novel 4-Hydroxyphenylpyruvate dioxygenase inhibiting-based herbicides被引量：2
《Advanced Agrochem》2023年第2期163-172,共10页Li-Jun Chen Guang-Yi Huang Jin Dong Zhuo-Mei Cai Bao-Qing Ye Qiong Chen Hong-Yan Lin 
the National Key Research and Development Program of China(No.2021YFD1700100);National Natural Science Foundation of China(No.22007035,21837001);Knowledge Innovation Program of Wuhan-Basic Research(No.2022013301015174);the Key Research and Development Program of Hubei Province(2022BBA001).
4-Hydroxyphenylpyruvate dioxygenase(EC 1.13.11.27,HPPD)is currently one of the popular targets of herbicide research,and herbicides targeting it have shown promising results in treating resistant weeds.However,the lon...
关键词：HPPD INHIBITOR PHARMACOPHORE Tetrazolium nicotinamide Herbicidal activity 
Chemistry-led investigations into the mode of action of NAMPT activators,resulting in the discovery of non-pyridyl class NAMPT activators被引量：1
《Acta Pharmaceutica Sinica B》2023年第2期709-721,共13页Siyuan Tang Miguel Garzon Sanz Oliver Smith Andreas Krämer Daniel Egbase Paul W.Caton Stefan Knapp Sam Butterworth 
funded by the China Sponsorship Council(No.201709110169);support by the SGC,a registered charity(number 1097737)that receives funds from AbbVie,Bayer Pharma AG,Boehringer Ingelheim,Canada Foundation for Innovation,Eshelman Institute for Innovation,Genome Canada,Innovative Medicines Initiative(EU/EFPIA),Janssen,Merck KGaA Darmstadt Germany,MSD,Novartis Pharma AG,Ontario Ministry of Economic Development and Innovation,Pfizer,S?o Paulo Research Foundation-FAPESP and Takeda;supported by the Frankfurt Cancer Institute(FCI);the DKTK translational cancer network;financial support by the European Union Horizon 2020 research and innovation program under grant agreement number 730872,project CALIPSOplus。
The cofactor nicotinamide adenine dinucleotide(NAD+)plays a key role in a wide range of physiological processes and maintaining or enhancing NAD+levels is an established approach to enhancing healthy aging.Recently,se...
关键词：Nicotinamide phosphoribosyl transferase activator Healthy aging Drug discovery BIOISOSTERES Medicinal chemistry 
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