Cardiovascular and nonalcoholic fatty liver disease:Sharing common ground through SIRT1 pathways  

作　　者：Kenneth Maiese 

机构地区：[1]National Heart,Lung,and Blood Institute,National Institutes of Health,Bethesda,MD 20810,United States

出　　处：《World Journal of Cardiology》2024年第11期632-643,共12页世界心脏病学杂志（英文）

基　　金：Supported by American Diabetes Association;American Heart Association;NIH NIEHS;NIH NIA;NIH NINDS;NS053956;NIH ARRA.

摘　　要：As a non-communicable disease,cardiovascular disorders have become the lea-ding cause of death for men and women.Of additional concern is that cardio-vascular disease is linked to chronic comorbidity disorders that include nonal-coholic fatty liver disease(NAFLD).NAFLD,also termed metabolic-dysfunction-associated steatotic liver disease,is the greatest cause of liver disease throughout the world,increasing in prevalence concurrently with diabetes mellitus(DM),and can progress to nonalcoholic steatohepatitis that leads to cirrhosis and liver fi-brosis.Individuals with metabolic disorders,such as DM,are more than two times likely to experience cardiac disease,stroke,and liver disease that includes NAFLD when compared individuals without metabolic disorders.Interestingly,cardiovascular disorders and NAFLD share a common underlying cellular me-chanism for disease pathology,namely the silent mating type information regu-lation 2 homolog 1(SIRT1;Saccharomyces cerevisiae).SIRT1,a histone deacetylase,is linked to metabolic pathways through nicotinamide adenine dinucleotide and can offer cellular protection though multiple avenues,including trophic factors such as erythropoietin,stem cells,and AMP-activated protein kinase.Translating SIRT1 pathways into clinical care for cardiovascular and hepatic disease can offer significant hope for patients,but further insights into the complexity of SIRT1 pathways are necessary for effective treatment regimens.

关 键 词：AMP-activated protein kinase Cardiovascular disease Diabetes mellitus ERYTHROPOIETIN Metabolic-dysfunction-associated steatotic liver disease NICOTINAMIDE Nicotinamide adenine dinucleotide Nonalcoholic fatty liver disease Silent mating type information regulation 2 homolog 1(Saccharomyces cerevisiae) Stem cells 

分 类 号：R54[医药卫生—心血管疾病] R575[医药卫生—内科学]