BIOISOSTERES

作品数：3被引量：2H指数：1
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相关机构：北京工业大学更多>>
相关期刊：《Science China Chemistry》《Acta Pharmaceutica Sinica B》更多>>
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Photoinduced generation of alkyl and phthalimide nitrogen radicals from N-hydroxyphthalimide esters for the synthesis of benzophenone-type bioisosteres
《Science China Chemistry》2024年第10期3389-3396,共8页Fei Li Jianyang Dong Huijuan Liao Jiayi Dang Xuechen Zhou Yuying Wang Chenya Wang Qin Jiang Gang Li Dong Xue 
supported by the National Natural Science Foundation of China(22171174);the Fundamental Research Funds for the Central Universities(GK202207015,GK202304033,GK202401008);the Innovation Capability Support Program of Shaanxi(2023-CX-TD-28);the Fundamental Science Research Project of Shaanxi for Chemistry,Biology(22JHZ002);the Natural Science Foundation of Shaanxi Province(2023-JC-YB-100);the China Postdoctoral Science Foundation(2023M732165);the Shaanxi Province Postdoctoral Science Foundation(2023BSHYDZZ107);the Young Talent Fund of Association for Science and Technology in Shaanxi,China(20240606)。
N-Hydroxyphthalimide(NHPI)esters have emerged as powerful sources of alkyl radicals generated by single-electron transfer,but homolysis of NHPI ester to produce an alkyl radical and a phthalimide nitrogen radical is s...
关键词：phthalimide nitrogen radicals aryl aldehydes hydrogen atom transfer bicycle[1.1.1]pentane ketones BIOISOSTERES 
Iodopentafluorosulfanylation of [1.1.1]propellane and further functionalizations被引量：1
《Science China Chemistry》2023年第10期2871-2877,共7页Xin Zhao Jia-Yi Shou Feng-Ling Qing 
supported by the National Natural Science Foundation of China (21991121);the National Key Research and Development Program of China (2021YFF0701700)。
Pentafluorosulfanylated(SF_(5^(-))) aromatics have shown great potential in drugs, and the bioisosteric replacement of aromatic ring with bicyclo[1.1.1]pentane(BCP) unit has attracted considerable attention recently. ...
关键词：pentafluorosulfanyl bicyclo[1.1.1]pentane(BCP) BIOISOSTERES PHOTOREDOX RADICAL 
Chemistry-led investigations into the mode of action of NAMPT activators,resulting in the discovery of non-pyridyl class NAMPT activators被引量：1
《Acta Pharmaceutica Sinica B》2023年第2期709-721,共13页Siyuan Tang Miguel Garzon Sanz Oliver Smith Andreas Krämer Daniel Egbase Paul W.Caton Stefan Knapp Sam Butterworth 
funded by the China Sponsorship Council(No.201709110169);support by the SGC,a registered charity(number 1097737)that receives funds from AbbVie,Bayer Pharma AG,Boehringer Ingelheim,Canada Foundation for Innovation,Eshelman Institute for Innovation,Genome Canada,Innovative Medicines Initiative(EU/EFPIA),Janssen,Merck KGaA Darmstadt Germany,MSD,Novartis Pharma AG,Ontario Ministry of Economic Development and Innovation,Pfizer,S?o Paulo Research Foundation-FAPESP and Takeda;supported by the Frankfurt Cancer Institute(FCI);the DKTK translational cancer network;financial support by the European Union Horizon 2020 research and innovation program under grant agreement number 730872,project CALIPSOplus。
The cofactor nicotinamide adenine dinucleotide(NAD+)plays a key role in a wide range of physiological processes and maintaining or enhancing NAD+levels is an established approach to enhancing healthy aging.Recently,se...
关键词：Nicotinamide phosphoribosyl transferase activator Healthy aging Drug discovery BIOISOSTERES Medicinal chemistry 
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