Ferroptosis mechanism and Alzheimer's disease  

作　　者：Lina Feng Jingyi Sun Ling Xia Qiang Shi Yajun Hou Lili Zhang Mingquan Li Cundong Fan Baoliang Sun 

机构地区：[1]Shandong Key Laboratory of TCM Multi-Target Intervention and Disease Control,the Second Affiliated Hospital of Shandong First Medical University,Taian,Shandong Province,China [2]Department of Internal Medicine,Taian Traffic Hospital,Taian,Shandong Province,China [3]Department of Neurology,the Third Affiliated Clinical Hospital of Changchun University of Chinese Medicine,Changchun,Jilin Province,China

出　　处：《Neural Regeneration Research》2024年第8期1741-1750,共10页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81501106(to CF);Fund of Taishan Scholar Project(to CF);the Natural Science Foundation of Shandong Province,No.ZR2020QH106(to YH);the Medical and Health Science and Technology Development Plan of Shandong Province,No.202203010799(to QS)。

摘　　要：Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms.This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms.Ferroptosis is a classic regulatory mode of cell death.Extensive studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s disease.This review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferro ptosis in Alzheimer’s disease.Our findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer’s disease.

关 键 词：Alzheimer’s disease apolipoprotein E Fe^(2+) ferroptosis glial cell glutathione peroxidase 4 imbalance in iron homeostasis lipid peroxidation regulated cell death system Xc^(-) 

分 类 号：R749.16[医药卫生—神经病学与精神病学]