分子骨架编辑在药物合成中的应用与展望  

Application and Prospect of Molecular Skeletal Editing in Drug Synthesis

作　　者：贺静远 王泽铠 戚显玮 陈开元 卞江[1] Jingyuan He;Zekai Wang;Xianwei Qi;Kaiyuan Chen;Jiang Bian(College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;School of Physics,Peking University,Beijing 100871,China)

机构地区：[1]北京大学化学与分子工程学院,北京100871 [2]北京大学物理学院,北京100871

出　　处：《大学化学》2023年第10期313-323,共11页University Chemistry

摘　　要：分子编辑是有机合成领域亘古不变的研究热点,其包括外围编辑与骨架编辑。在过去,分子编辑往往着重于C―H键的外围编辑,而骨架编辑则是近年来新兴起的方法学。这一类反应操作简单,专一性强,可以大幅简化合成路线,在药物合成与开发领域应用广泛。本文基于常见的几类分子编辑反应,通过与传统方法对比的方式介绍两例分子骨架编辑在药物合成中的应用,并通过对该领域前沿发展的介绍,对该方法学的未来应用进行展望。Molecular editing,including peripheral and skeletal editing,is an area of interest in the field of organic synthesis.Typically,the peripheral editing of C―H bonds is conventionally used for molecular editing.By contrast,skeletal editing is a novel method,which has broader applications in total synthesis and drug development,with advantages of easy operation,high specificity,and simple synthetical routes.This review introduces two skeletal editing examples using common reactions.By comparisons with conventional methods,the applications of molecular editing in drug synthesis are revealed.Moreover,this review predicts the future applications of molecular editing by presenting some state-of-the-art developments in this field.

关 键 词：分子编辑 骨架编辑 药物合成 药物开发 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]