The inferior frontal gyrus and familial risk for bipolar disorder  

作　　者：Kun Qin John A.Sweeney Melissa P.DelBello 

机构地区：[1]Department of Psychiatry and Behavioral Neuroscience,University of Cincinnati College of Medicine,Cincinnati,OH 45219,USA [2]Huaxi MR Research Center(HMRRC),Department of Radiology,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Psychoradiology》2022年第4期171-179,共9页精神影像学（英文）

摘　　要：Bipolar disorder(BD)is a familial disorder with high heritability.Genetic factors have been linked to the pathogenesis of BD.Relatives of probands with BD who are at familial risk can exhibit brain abnormalities prior to illness onset.Given its involvement in prefrontal cognitive control and in frontolimbic circuitry that regulates emotional reactivity,the inferior frontal gyrus(IFG)has been a focus of research in studies of BD-related pathology and BD-risk mechanism.In this review,we discuss multimodal neuroimaging findings of the IFG based on studies comparing at-risk relatives and low-risk controls.Review of these studies in at-risk cases suggests the presence of both risk and resilience markers related to the IFG.At-risk individuals exhibited larger gray matter volume and increased functional activities in IFG compared with low-risk controls,which might result from an adaptive brain compensation to support emotion regulation as an aspect of psychological resilience.Functional connectivity between IFG and downstream limbic or striatal areas was typically decreased in at-risk individuals relative to controls,which could contribute to risk-related problems of cognitive and emotional control.Large-scale and longitudinal investigations on at-risk individuals will further elucidate the role of IFG and other brain regions in relation to familial risk for BD,and together guide identification of at-risk individuals for primary prevention.

关 键 词：bipolar disorder PREFRONTAL LIMBIC familial risk RESILIENCE magnetic resonance imaging genetic risk 

分 类 号：R749[医药卫生—神经病学与精神病学]