Altered cortical morphology in major depression disorder patients with suicidality  

作　　者：Huiru Li Huawei Zhang Li Yin Feifei Zhang Ziqi Chen Taolin Chen Zhiyun Jia Qiyong Gong 

机构地区：[1]Huaxi MR Research Center(HMRRC),Functional and molecular imaging Key Laboratory of Sichuan Province,Department of Radiology,West China Hospital of Sichuan University,Chengdu,China,610041 [2]Department of Psychiatry,West China Hospital of Sichuan University,Chengdu,China,610041 [3]Department of Nuclear Medicine,West China Hospital of Sichuan University,Chengdu,China,610041 [4]Psychoradiology Research Unit of Chinese Academy of Medical Sciences,Chengdu,China,610041

出　　处：《Psychoradiology》2021年第1期13-22,共10页精神影像学（英文）

基　　金：supported by the National Natural Science Foundation(Grant Nos.81971595,81621003,81820108018,81801681 and 81801357);the Science and Technology Department of Sichuan Province(No.2020YFS0118);the 1•3•5 Project for Disciplines of Excellence–Clinical Research Incubation Project,West China Hospital,Sichuan University(Grant No.2020HXFH005).

摘　　要：Background:Major depressive disorder(MDD)is associated with high risk of suicide,but the biological under-pinnings of suicidality in MDD patients are far from conclusive.Previous neuroimaging studies using voxel-based morphometry(VBM)demonstrated that depressed individuals with suicidal thoughts or behaviors exhibit specific cortical structure alterations.To complement VBM findings,surface-based morphometry(SBM)can pro-vide more details into gray matter structure,including the cortical complexity,cortical thickness and sulcal depth for brain images.Objective:This study aims to use SBM to investigate cortical morphology alterations to obtain evidence for neuroanatomical alterations in depressed patients with suicidality.Methods:Here,3D T1-weighted MR images of brain from 39 healthy controls,40 depressed patients without suicidality(patient controls),and 39 with suicidality(suicidal groups)were analyzed based on SBM to estimate the fractal dimension,gyrification index,sulcal depth,and cortical thickness using the Computational Anatomy Toolbox.Correlation analyses were performed between clinical data and cortical surface measurements from patients.Results:Surface-based morphometry showed decreased sulcal depth in the parietal,frontal,limbic,occipital and temporal regions and decreased fractal dimension in the frontal regions in depressed patients with sui-cidality compared to both healthy and patient controls.Additionally,in patients with depression,the sulcal depth of the left caudal anterior cingulate cortex was negatively correlated with Hamilton Depression Rating Scale scores.Conclusions:Depressed patients with suicidality had abnormal cortical morphology in some brain regions within the default mode network,frontolimbic circuitry and temporal regions.These structural deficits may be associated with the dysfunction of emotional processing and impulsivity control.This study provides insights into the underlying neurobiology of the suicidal brain.

关 键 词：major depressive disorder SUICIDALITY surface-based morphometry fractal dimension sulcal depth psychoradiology 

分 类 号：R74[医药卫生—神经病学与精神病学]