丁苯酞氯化钠注射液联合尤瑞克林治疗脑梗死患者的效果观察  

Observation on the effect of butylphthalide and sodium chloride injection combined with urinary kallidinogenase in the treatment of patients with cerebral infarction

作　　者：张月 ZHANG Yue(Department of Neurology,Jinzhou Central Hospital,Jinzhou 121000,China)

机构地区：[1]锦州市中心医院神经内科,121000

出　　处：《中国现代药物应用》2023年第21期69-71,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 观察丁苯酞氯化钠注射液联合尤瑞克林治疗脑梗死患者的效果。方法 100例脑梗死患者为研究对象,按照随机数字表法分为对照组及观察组,各50例。对照组单独使用尤瑞克林治疗,观察组使用丁苯酞氯化钠注射液联合尤瑞克林治疗。比较两组临床疗效,用药前后的神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)评分]、炎症指标[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]水平。结果 用药14 d后,观察组总有效率96.00%高于对照组的78.00%,差异具有统计学意义(P<0.05)。用药前,两组NIHSS评分、IL-6、hs-CRP比较,差异无统计学意义(P>0.05);用药14 d后,两组NIHSS评分、IL-6、hs-CRP均低于本组用药前,且观察组NIHSS评分(3.29±1.11)分、hs-CRP(5.39±1.27)mg/L、IL-6(15.20±2.13)pg/ml低于对照组的(5.25±2.19)分、(11.19±2.09)mg/L、(22.10±3.01)pg/ml,差异具有统计学意义(P<0.05)。结论 丁苯酞氯化钠注射液联合尤瑞克林用药方案可提高脑梗死患者的救治效果,控制机体炎症反应,改善神经功能。Objective To observe the effect of butylphthalide and sodium chloride injection combined with urinary kallidinogenase in the treatment of patients with cerebral infarction.Methods A total of 100 patients with cerebral infarction were studied and divided into the control group and the observation group according to random numerical table,with 50 cases in each group.The control group was treated with urinary kallidinogenase,and the observation group was treated with butylphthalide and sodium chloride injection and urinary kallidinogenase.Both groups were compared in terms of clinical efficacy,as well as the level of neurological impairment[National Institutes of Health Stroke Scale(NIHSS)score]and inflammation indicators[interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)]before and after treatment.Results After 14 d of treatment,the total effective rate of the observation group was 96.00%,which was higher than that of 78.00%of the control group,and the difference was statistically significant(P<0.05).Before medication,there was no statistically significant difference in NIHSS score,IL-6 and hs-CRP between the two groups(P>0.05).After 14 d of treatment,NIHSS score,IL-6 and hs-CRP in both groups were lower than those before treatment in this group;the observation group had NIHSS score of(3.29±1.11)points,hs-CRP of(5.39±1.27)mg/L and IL-6 of(15.20±2.13)pg/ml,which were lower than those of(5.25±2.19),(11.19±2.09)mg/L and(22.10±3.01)pg/ml in the control group;the differences were statistically significant(P<0.05).Conclusion The combination of butylphthalide and sodium chloride injection and urinary kallidinogenase can improve the treatment effect of the study subjects,control the body's inflammatory response,and improve their neurological function.

关 键 词：脑梗死 丁苯酞氯化钠注射液 尤瑞克林 效果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]