中药中真菌毒素检测的误差来源与控制方法研究进展  

Research progress in error sources and control methods of mycotoxin detection in traditional Chinese medicine

作　　者：李海亮 李耀磊[1] 王赵[1] 昝珂[1] 刘丽娜[1] 金红宇[1] 马双成[1] LI Hailiang;LI Yaolei;WANG Zhao;ZAN Ke;LIU Lina;JIN Hongyu;MA Shuangcheng(National Institutes for Food and Drug Control,Beijing 102629,China)

机构地区：[1]中国食品药品检定研究院,北京102629

出　　处：《中国药物警戒》2023年第10期1184-1188,共5页Chinese Journal of Pharmacovigilance

基　　金：国家重点研发计划(2022YFC3501500)。

摘　　要：目的总结中药中真菌毒素的污染现状,分析真菌毒素检测中的误差来源及控制方法,为中药真菌毒素检测结果的可靠性提供参考。方法采用理论研究与文献调研等方法,总结中药真菌毒素检测过程中的误差来源,并为误差控制的方法提出建议。结果采样作为真菌毒素检测的第一步,直接关系到检测结果的准确性,是最大的误差来源;样品制备与分析结果直接相关,是检测结果正确性的重要保障。为了保证真菌毒素检测结果的准确性,应采用科学、合理的采样方案,使用适宜的样品制备方法和灵敏、准确的分析技术。结论本文从采样、样品制备、分析检测等方面阐述真菌毒素检测中的误差来源和控制方法,为提高中药真菌毒素检测的分析质量、降低分析风险提供一定的参考。Objective To study the current mycotoxin contamination in traditional Chinese medicine,analyze the error sources and control methods of mycotoxin detection,and provide reference for reliable detection of mycotoxin in traditional Chinese medicine.Methods Theoretical research and literature review were used to summarize the sources of errors in the detection of mycotoxin,a traditional Chinese medicine.Recommendations were offered about the methods of error control.Results Sampling,as the first step of mycotoxin detection,was directly related to the accuracy of detection results,but was the biggest source of errors.Sample preparation was directly correlated with results of analysis and served as an important guarantee of the accuracy of test results.In order to ensure the accuracy of results of mycotoxin detection,a well-designed sampling scheme,appropriate sample preparation methods and sensitive and accurate analysis techniques should be used.Conclusion This paper has explored the sources of errors and control methods of mycotoxin detection in terms of sampling,sample preparation,analysis and detection so as to provide reference for improving the quality of analysis and reducing the analysis risk of mycotoxin detection in traditional Chinese medicine.

关 键 词：中药 真菌毒素 误差 控制方法 检测 

分 类 号：R927.1[医药卫生—药学]