PET自动给药系统联合耐高压经外周静脉置入中心静脉导管在^(18)F-FDG显像中的临床应用  

Clinical application of PET automatic drug infusion system combined with power peripherally inserted central catheter in ^(18)F-FDG PET/CT imaging

作　　者：戚勤励 赵凌舟[1] 陈栋晖 周兴梅 刘长存[1] 吴珊[1] 张英[1] 赵晋华[1] Qi Qinli;Zhao Lingzhou;Chen Donghui;Zhou Xingmei;Liu Changcun;Wu Shan;Zhang Ying;Zhao Jinhua(Department of Nuclear Medicine,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Comprehensive Cancer Center,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Vascular Access Clinic,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属第一人民医院核医学科,上海200080 [2]上海交通大学医学院附属第一人民医院肿瘤中心,上海200080 [3]上海交通大学医学院附属第一人民医院血管通路门诊,上海200080

出　　处：《中华核医学与分子影像杂志》2023年第11期684-688,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金(81971647);上海市松江区科学技术攻关项目(22SJKJGG10);上海市第一人民医院医院感染管理2022课题(SYYG20221030)。

摘　　要：目的评价PET自动给药系统联合耐高压经外周静脉置入中心静脉导管(PICC)注射^(18)F-FDG的临床应用的可行性。方法前瞻性纳入2021年12月至2022年7月间于上海交通大学医学院附属第一人民医院行^(18)F-FDG PET/CT检查的50例恶性肿瘤患者,采用交替入组的方法分为耐高压PICC组[男15例,女10例,年龄(48.4±16.7)岁]和外周静脉注射组[男12例,女13例,年龄(50.4±14.7)岁]。将PET自动给药系统分别连接提前建立的耐高压PICC和外周静脉穿刺的注射通道,完成^(18)F-FDG注射,行常规PET/CT显像;记录患者血糖、体质量、处方剂量和注射剂量,测量2组肝脏和上腔静脉与右心房交界处SUV_(max),组间比较行两独立样本t检验;判读耐高压PICC组患者^(18)F-FDG注射后耐高压PICC尖端位置。结果耐高压PICC组和外周组患者肝脏SUV_(max)分别为2.54±0.50和2.57±0.31,上腔静脉与右心房交界处SUV_(max)分别为1.68±0.25和1.63±0.22,差异均无统计学意义(t值:0.37、-0.78,P值:0.716、0.441)。2组患者的血糖、体质量、处方剂量和注射剂量差异也无统计学意义(t值:0.00~0.13,均P>0.05);注射剂量/处方剂量比值分别为0.9983±0.0073和0.9976±0.0165,注射精度高;导管末端无明显药物残留,显像质量无差别。耐高压PICC组患者注射后导管末端位置均位于T5~T8水平,符合耐高压PICC置管规范。结论PET自动给药系统联合耐高压PICC注射^(18)F-FDG具有可行性,有助于减少注射穿刺次数。Objective To evaluate the feasibility of PET automatic drug infusion system combined with power peripherally inserted central catheter(PICC)for ^(18)F-FDG injection and PET/CT imaging.Methods Fifty patients with malignant neoplasms who underwent ^(18)F-FDG PET/CT imaging in Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine between December 2021 to July 2022 were prospectively enrolled.They were equally divided into power PICC group and peripheral venipuncture group.PET automatic drug infusion system was respectively connected with the pre-established channels of power PICC and peripheral venipuncture for ^(18)F-FDG injection.Each patient underwent a routine PET/CT imaging at 1 h post-injection.The blood glucose,body weight,prescription dose and injection dose were recorded,and SUVmax in the liver and cavoatrial junction were measured in both groups.The independent-sample t test was performed to compare the differences between 2 groups.The power PICC tip positions after ^(18)F-FDG injection in power PICC group were observed.Results The liver SUVmax in the power PICC group and peripheral group were 2.54±0.50 and 2.57±0.31(t=0.37,P=0.716),and the SUVmax of cavoatrial junction in the 2 groups were 1.68±0.25 and 1.63±0.22(t=-0.78,P=0.441),respectively.No significant differences were found in blood glucose,body weight,prescription dose and injection dose between the 2 groups(t values:0.00-0.13,all P>0.05).The ratios of injection dose to prescription dose in the 2 groups were 0.9983±0.0073 and 0.9976±0.0165,respectively,indicating high injection accuracy of the injection methods.No obvious drug residue was displayed at the end of catheter,resulting in good imaging quality.All the tip positions after injection were between T5 and T8,in line with the standardization management of power PICC.Conclusion PET automatic drug infusion system combined with power PICC can be safely used for ^(18)F-FDG injection and PET/CT imaging with less injection puncture.

关 键 词：输注泵 中心静脉导管 注射 静脉内 氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术 X线计算机 

分 类 号：R730.44[医药卫生—肿瘤]