Boosting T cell immunity against cytomegalovirus:a potential strategy combating human aging and age-related diseases  

作　　者：Matthias Wirth Walburgis Brenner Oliver H.Kramer 

机构地区：[1]Department of Hematology,Oncology and Cancer Immunology,Campus Benjamin Franklin,Charite-Universitatsmedizin Berlin,corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin,Berlin,Germany [2]University Medical Center Gottingen,Department of General,Visceral and Pediatric Surgery,Gottingen,Germany [3]German Cancer Consortium(DKTK),German Cancer Research Center(DKFZ),Heidelberg,Germany [4]Clinic for Obstetrics and Women's Health,University Medical Center,Johannes Gutenberg University Mainz,Langenbeckstr.1,55131 Mainz,Germany [5]Department of Toxicology,University Medical Center,Mainz,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第10期4417-4418,共2页信号转导与靶向治疗（英文）

摘　　要：In a recent publication in Cell,Hasegawa and colleagues reveal that cytotoxic CD4-positive cytotoxic T lymphocytes(CD4+CTLs)eliminate senescent fibroblasts with a surface expression of the immunologically important human leukocyte antigen class Il(HLA-)and the human cytomegalovirus glycoprotein B(HCMV-gB).1 This implies that a virome-immune cell interaction controls the fate of human skin cells that are linked to the aging process and associated diseases.

关 键 词：immunity CYTOMEGALOVIRUS CYTOTOXIC 

分 类 号：R392[医药卫生—免疫学]