Fumarate hydratase:a new checkpoint of metabolic regulation in inflammatory macrophages  

作　　者：Aicha Jeridi Theodore S.Kapellos Ali Onder Yildirim 

机构地区：[1]Comprehensive Pneumology Center(CPC),Institute of Lung Health and Immunity(LHI),Member of the German Center for Lung Research(DZL),Helmholtz Munich,Munich,Germany [2]Institute of Experimental Pneumology,University Hospital,Ludwig-Maximilians University,München,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第10期4421-4423,共3页信号转导与靶向治疗（英文）

摘　　要：A recent article published by Hooftman et al.1 in Nature identified a crucial function for fumarate hydratase(FH)in bone marrow-derived macrophages(BMDMs).Pharmacological inhibition or genetic ablation of FH led to increased fumarate levels and downstream suppression of mitochondrial respiration implying the importance of cellular metabolic states and cytokine balance shift in innate immunity.

关 键 词：al. MACROPHAGES RESPIRATION 

分 类 号：R392[医药卫生—免疫学]