2007—2017年江苏省南通市肿瘤医院乳腺癌住院患者生存率分析  

Analysis of Survival Among Breast Cancer Inpatients in Nantong Tumor Hospital from 2007 to 2017

作　　者：陈海珍[1] 徐红[2] 吉光 王书兰 季佳慧 韩建周 杨艳蕾 王军 邵晶晶[1] 蔡波[2] 陈建国[1,8] CHEN Haizhen;XU Hong;JI Guang;WANG Shulan;JI Jiahui;HAN Jianzhou;YANG Yanlei;WANG Jun;SHAO Jingjing;CAI Bo;CHEN Jianguo(Nantong Tumor Hospital/Affiliated Tumor Hospital of Nantong University,Nantong 226361,China;Nantong Center for Disease Control and Prevention,Nantong 226007,China;Haian Center for Disease Control and Prevention,Haian 226600,China;Rugao Center for Disease Control and Prevention,Rugao 226500,China;Rudong Center for Disease Control and Pre-vention,Rudong 226400,China;Tongzhou Center for Disease Control and Prevention,Nan-tong 226300,China;Haimen Center for Disease Control and Prevention,Nantong 226100,China;Qidong Liver Cancer Institute/Qidong People’s Hospital/Affiliated Qidong Hospital of Nantong University,Qidong 226200,China)

机构地区：[1]南通市肿瘤医院/南通大学附属肿瘤医院,江苏南通226361 [2]南通市疾病预防控制中心,江苏南通226007 [3]海安市疾病预防控制中心,江苏海安226600 [4]如皋市疾病预防控制中心,江苏如皋226500 [5]如东县疾病预防控制中心,江苏如东226400 [6]南通市通州区疾病预防控制中心,江苏南通226300 [7]南通市海门区疾病预防控制中心,江苏南通226100 [8]启东肝癌防治研究所/启东市人民医院/南通大学附属启东医院,江苏启东226200

出　　处：《中国肿瘤》2023年第11期820-826,共7页China Cancer

基　　金：南通市2022年度人口发展研究课题(20220914)。

摘　　要：[目的]对2007—2017年南通市肿瘤医院乳腺癌住院病例进行生存率分析。[方法]采用以医院为基础的肿瘤随访结合现场以人群为基础的肿瘤随访方法,随访截止于2020年12月31日。以寿命表法计算观察生存率(OSR),用SPSS 22.0软件进行统计分析并绘制曲线图,采用Wilcoxon统计量Gehan值作生存率比较。[结果]2007—2017年登记乳腺癌住院病例3315例,经随访获得癌症生存结局3291例(随访成功率为99.28%),其中男性31例(0.94%),女性3260例(99.06%)。首次入院时平均年龄为(53.44±10.88)岁;以35~59岁为最多见(68.52%),其次为60~79岁(26.86%)。每例患者平均住院(5.66±5.40)次。男性乳腺癌患者1、3、5及10年OSR分别为83.87%、74.19%、63.21%及19.39%;女性患者则分别为91.66%、79.02%、73.14%及63.37%,差异无统计学意义(P=0.078)。15~34岁、35~59岁、60~79岁及80~99岁各年龄组5年OSR分别为73.74%、75.71%、67.03%及56.80%(P<0.001)。2007—2012年及2013—2017年两个时期的5年OSR分别为69.42%及76.10%(P<0.001)。乳腺癌生存率存在地区差异。TNM分期显示Ⅰ期、Ⅱ期、Ⅲ期及Ⅳ期病例的5年OSR分别为94.30%、92.58%、71.52%及31.37%(P<0.001)。[结论]2007—2017年乳腺癌患者以中老年女性为主,青壮年女性乳腺癌的生存率较高;分期为Ⅰ期、Ⅱ期的早期乳腺癌患者预后较好。应该加强乳腺癌的综合防治能力。[Purpose]To analyze the survival of breast cancer inpatients at Nantong Tumor Hospi-tal from 2007 to 2017.[Methods]Patients with breast cancer who were residents in Nantong area and admitted in Nantong Tumor Hospital from 2007 to 2017 were followed up until December 31,2020.The observed survival rate(OSR)was calculated using the life table method,and analyzed using SPSS 22.0 software.The Wilcoxon statistic(Gehan value)was employed for survival compari-son.[Results]A total of 3315 registered breast cancer inpatients between 2007 and 2017 were identified,and the outcomes were followed in 3291 cases including 31 males(0.94%)and 3260 females(99.06%),with a follow-up rate of 99.28%.The ages of patients upon initial admission were(53.44±10.88)years old.The age group with the highest incidence was 35~59 years old(68.52%),followed by 60~79 years old(26.86%).The average number of hospital admission was 5.66±5.40 times.The 1-,3-,5-,and 10-year OSRs for male breast cancer patients were 83.87%,74.19%,63.21%,and 19.39%,respectively;and those for female patients were 91.66%,79.02%,73.14%,and 63.37%,respectively(P=0.078).The 5-year OSR for the age groups of 15~34,35~59,60~79,and 80~99 years old were 73.74%,75.71%,67.03%,and 56.80%,respectively(P<0.001).The 5-year OSR for the periods 2007—2012 and 2013—2017 was 69.42%and 76.10%,respectively(P<0.001).There were regional variations in breast cancer survival.The 5-year OSRs of stagesⅠ,Ⅱ,Ⅲ,andⅣbreast cancer were 94.30%,92.58%,71.52%,and 31.37%,respectively(P<0.001).[Conclusion]The study indicates that breast can-cer primarily affected middle-aged and elderly females,with higher survival among younger fe-male patients and poorer survival among those aged 80 and above;early-stage patients(stageⅠandⅡ)exhibit better prognosis compared to late-stage patients(stageⅣ).

关 键 词：乳腺癌 肿瘤登记 随访 生存率 江苏 

分 类 号：R737.9[医药卫生—肿瘤]