肿瘤血管渗透和异常增生及对肿瘤治疗影响的研究进展  

Effects of Tumor Vascular Permeability and Abnormal Proliferation on Tumor Treatment

作　　者：刘帅 陈志浩 沈宇杰 杨红 LIU Shuai;CHEN Zhihao;SHEN Yujie;YANG Hong(Xi’an Medical University,Xi’an 710021,China;The First Affiliated Hospital of Air Force Military Medical University,Xi’an 710032,China)

机构地区：[1]西安医学院,陕西西安710021 [2]空军军医大学第一附属医院,陕西西安710032

出　　处：《中国肿瘤》2023年第11期870-877,共8页China Cancer

基　　金：国家自然科学基金(82172993,32101055)。

摘　　要：肿瘤的发生及进展伴随着高水平的异常血管生成。其中肿瘤血管的渗透和异常增生在肿瘤间质流体压力升高及其所导致的肿瘤药物治疗抵抗中发挥着重要作用。全文综述肿瘤血管内皮细胞、周细胞的异常生物学行为调节的肿瘤血管渗透性和异常增生所介导的肿瘤间质流体压力升高,并分析了肿瘤微环境下相关信号分子通路对血管内皮细胞和周细胞异常生物学行为的多种调控机制,以期为进一步深入探究异常肿瘤血管引起的间质流体压力升高对药物治疗的抵抗提供理论依据。The tumor progression is accompanied by abnormal angiogenesis with the increased en-dothelial cell proliferation and permeability of blood vessels,which cause the elevated interstitial fluid pressure inducing the resistance to drug therapy.This paper reviews the abnormal biological behavior of tumor vascular endothelial cells and pericytes,and their regulatory mechanisms of tu-mor interstitial fluid pressure and related signaling molecular pathways in the tumor microenviron-ment,to provide information for further exploration of antivascular therapy to improve the efficacy of cancer drug treatment.

关 键 词：肿瘤血管 血管渗透性 血管增生 治疗 间质流体压力 

分 类 号：R73-31[医药卫生—肿瘤]