嗅觉受体在乳腺癌中的异位表达及作用机制研究进展  

Ectopic Expression of Olfactory Receptors and Its Mechanism in Breast Cancer

作　　者：王玥 刘娜[2] 李明[2] WANG Yue;LIU Na;LI Ming(School of Clinical Medicine,Weifang Medical University,Weifang 261053,China;Qilu Hospital of Shandong University Dezhou Hospital,Dezhou 253000,China)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261053 [2]山东大学齐鲁医院德州医院,山东德州253000

出　　处：《肿瘤学杂志》2023年第9期749-753,共5页Journal of Chinese Oncology

基　　金：山东省医学会乳腺疾病科研专项资金(YXH2021ZX059)。

摘　　要：嗅觉受体(olfactory receptors,ORs)现定位于嗅觉上皮,主要功能是识别不同气味。近年来研究发现某些嗅觉受体在乳腺癌中存在异位表达,并与乳腺癌的发生、进展及治疗相关。全文对乳腺癌中相关ORs的表达、生物学特点及作用机制进行总结,探讨ORs作为乳腺癌肿瘤标志物的可能性以及在治疗中的潜在作用。Olfactory receptors(ORs)are primarily located in the olfactory epithelium with the function of recognizing diverse odors.Recently,ectopic expression of ORs has been reported in breast cancer and it may be involved in development of breast cancer.In this paper the expression,biological characteristics and regulatory mechanisms of ORs abnormally expressed in breast cancer are reviewed and the potential clinical applications of ORs as diagnostic biomarkers and treatment targets of breast cancer are discussed.

关 键 词：乳腺癌 嗅觉受体 异位表达 

分 类 号：R737.9[医药卫生—肿瘤]