Informational Polymers with Precise Carbamate Sequences  

作　　者：Itab Youssef Svetlana Samokhvalova Isaure Sergent Laurence Charles Jean-Francois Lutz 

机构地区：[1]Universite de Strasbourg,CNRS,ISIS,67000 Strasbourg,France [2]Universite de Strasbourg,CNRS,Institut Charles Sadron UPR22,67034 Cedex 2 Strasbourg,France [3]Aix Marseille Universite,CNRS,UMR 7273,Institute of Radical Chemistry,13397 Cedex 20 Marseille,France

出　　处：《Precision Chemistry》2023年第8期480-484,共5页精准化学（英文）

基　　金：the CSC Graduate School funded by the French National Research Agency(CSC-IGS ANR-17-EURE-0016)for a PhD fellowship.

摘　　要：Sequence-defined oligocarbamates were synthesized by orthogonal iterative chemistry on a modified Wang solid support.In this approach,amino alcohol building blocks,containing either primary or secondary amines,were used in order to obtain ondemand either a classical urethane motif−NH−CO−O−or a Nsubstituted urethane linkage−NR−CO−O−.Hence,aperiodic carbamate sequences could be easily prepared in this work.Polymers with different monomer sequences and chain-length were synthesized.Characterization by NMR,SEC and ESI-MS indicated formation of near-monodisperse polymers.Furthermore,these informational oligocarbamates were sequenced by MS/MS.Very interestingly,it was found that a fully orthogonal fragmentation of−NH−CO−O−urethane motifs occurs in these macromolecules.

关 键 词：Sequence-controlled polymers Information-containing polymers SEQUENCING Solid-phase synthesis Mass spectrometry 

分 类 号：O62[理学—有机化学]